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Technical Data
| Formula | C17H25NO4.HCl |
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| Molecular Weight | 343.85 | CAS No. | 35543-24-9 | |
| Solubility (25°C)* | In vitro | Water | 69 mg/mL (200.66 mM) | |
| DMSO | 31 mg/mL (90.15 mM) | |||
| Ethanol | 7 mg/mL (20.35 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Buflomedil HCl(NSC 759291) is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease; A nonselective alpha adrenergic receptor inhibitor. |
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| In vitro | Buflomedil increases intracellular levels of cAMP in human keratinocytes, either secondary to phosphodiesterase inhibition (PTX) or adenyl-cyclase stimulation (BC). Buflomedil diminishes TPA-induced TNF-alpha and IL-8 release from keratinocytes; in the case of IL-8 it is possible that this inhibition occur to transcriptional level. [1] Buflomedil significantly inhibits epinephrine-induced aggregation at the micromolar level. Buflomedil results in a weak inhibition of ADP- and collagen-induced aggregation. Buflomedil inhibits granular secretion and the interaction of fibrinogen with its receptor on platelet. [2] Buflomedil hypochloride improves the capillary perfusion in such related situations, evoking a possible effect upon neutrophils. Buflomedil decreases 100% of histamine related neutrophil adhesion (flow system) and partially inhibits adhesion after IL-1-4 hours (flow and stable systems). Buflomedil decreases the expression of P-selectin at the surface of endothelial cells and hypoxia induced neutrophil adhesion. [3] |
| In vivo | Buflomedil (6 mg/kg) increases flap survival in nicotine treated rats. [4] Buflomedil (3 mg/kg) significantly reduces both post-ischemic capillary perfusion failure and leukocyte adherence in venules. [5] Buflomedil reduces the vasodilation evoked by phentolamine and potentiates its depressive effect on vasomotion frequency and amplitude in the hamster cheek pouch. [6] |
Protocol (from reference)
References
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.