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Technical Data
| Formula | C21H22O11 |
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| Molecular Weight | 450.39 | CAS No. | 29838-67-3 | |
| Solubility (25°C)* | In vitro | DMSO | 90 mg/mL (199.82 mM) | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities. |
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| In vitro | In vitro, astilbin inhibits Th17 cell differentiation and IL-17 secretion of isolated T cells, and inhibits Jak/Stat3 signaling in Th17 cells, while up-regulating Stat3 inhibitor SCOSE3 expression in psoriatic lesions. Astilbin has been reported to possess multiple clinically relevant bioactivities, including antioxidant, anti-inflammatory, anti-arthritic, and anti-diabetic nephropathy properties. Nevertheless, the molecular mechanisms by which astilbin interacts with inflammatory processes are poorly understood. Astilbin not only inhibits T lymphocyte function in acute heart allograft rejection, but also inhibits migration and antigen presenting of dendritic cells (DCs)[1]. |
| In vivo | Astilbin is reported to reduce activation of both T and B cells in lupus-prone mice. It significantly inhibits inflammatory responses and keratinocyte over-proliferation in a mouse model of imiquimod (IMQ)-induced psoriasis[1]. Astilbin undergoes extensive biotransformation specifically due to enzyme catechol-O-methyl transferase. It gives rise to 3′-O-methylastilbin, a major metabolite of astilbin, which plays important role against the inhibition activated T lymphocytes. The pharmacokinetic parameters of astilbin followed by intragastric administration astilbin (40 mg/kg): Cmax=37.7±14.7 ng/mL, Tmax=25.8±34.3 min, t1/2=161.6±44.1 min[2]. |
Protocol (from reference)
| Cell Assay:[1] |
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| Animal Study:[1] |
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References
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Selleck's Astilbin has been cited by 1 publication
| Ethanol extract from Astilbe chinensis inflorescence suppresses inflammation in macrophages and growth of oral pathogenic bacteria [ PLoS One, 2024, 19(7):e0306543] | PubMed: 38959234 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.