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Technical Data
| Formula | C41H43ClFN9O6 |
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| Molecular Weight | 812.29 | CAS No. | 2222112-77-6 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (123.1 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR. ARV-110 completely degrades androgen receptor (AR) in all cell lines tested with DC50 of < 1 nM. ARV-110 can be used for the research of prostate cancer. | ||
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| In vitro | Orally bioavailable ARV-110 demonstrates robust AR degradation potency and consistent functional activity in various in vitro and in vivo systems thought to represent the shortcomings of current prostate cancer treatment regimens. |
Protocol (from reference)
| Cell Assay: |
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References
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Selleck's Bavdegalutamide (ARV-110) has been cited by 2 publications
| Decreased AMPK/SIRT1/PDK4 induced by androgen excess inhibits human endometrial stromal cell decidualization in PCOS [ Cell Mol Life Sci, 2024, 81(1):324] | PubMed: 39080028 |
| Recovery of protein synthesis to assay DNA repair activity in transcribed genes in living cells and tissues [ Nucleic Acids Res, 2023, gkad642] | PubMed: 37522336 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.