Arteether

Catalog No.S3889 Batch:S388901

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Technical Data

Formula

C17H28O5
Molecular Weight 312.40 CAS No. 75887-54-6
Solubility (25°C)* In vitro DMSO 62 mg/mL (198.46 mM)
 
 
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
3.1mg/ml Taking the 1 mL working solution as an example, add 50 μL of 62 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
3.1mg/ml Taking the 1 mL working solution as an example, add 50 μL of 62 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.
In vitro Arteether is an oil-soluble derivative of artemisinin with an endoperoxide bridge that can induce apoptosis in tumor cells but not in the normal cells. Arteether and other derivatives show a dose-dependent manner to interact with immune cells[1].
In vivo Intratumoral injection of Arteether could have a significant reduction in tumor growth rate. Intra-tumoral injection of Arteether, as a loco-regional administration, may yield higher drug concentration in tumor and may reduce the risk of systemic adverse effects[1].

Protocol (from reference)

Animal Study:[1]
  • Animal Models

    Balb/c mice

  • Dosages

    6 mg/kg/day

  • Administration

    via intratumoral (IT) route

Selleck's Arteether has been cited by 1 publication

Anti-SARS-CoV-2 Potential of Artemisinins In Vitro [ ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00522] PubMed: 32786284

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.