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Technical Data
| Formula | C25H34N6O8S2 |
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| Molecular Weight | 610.7 | CAS No. | 870087-36-8 | |
| Solubility (25°C)* | In vitro | Water | 33 mg/mL (54.03 mM) | |
| DMSO | 20 mg/mL (32.74 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Apilimod mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM. | ||||||||
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Protocol (from reference)
References
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Selleck's Apilimod mesylate has been cited by 3 publications
| PIKfyve controls dendritic cell function and tumor immunity [ bioRxiv, 2024, 2024.02.28.582543] | PubMed: 38464258 |
| Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors [ Stem Cell Reports, 2022, 17(2):397-412] | PubMed: 35063131 |
| Mitochondria-lysosome membrane contacts are defective in GDAP1-related Charcot-Marie-Tooth disease [ Hum Mol Genet, 2021, 29(22):3589-3605] | PubMed: 33372681 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.