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Technical Data
| Formula | C17H19N3.HCl |
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| Molecular Weight | 301.81 | CAS No. | 2508-72-7 | |
| Solubility (25°C)* | In vitro | DMSO | 60 mg/mL (198.8 mM) | |
| Ethanol | 10 mg/mL (33.13 mM) | |||
| Water | 5 mg/mL (16.56 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Antazoline hydrochloride(Phenazoline hydrochloride) is a first-generation antihistamine with anticholinergic properties and is commonly used to relieve nasal congestion and in eye drops. Antazoline hydrochloride exhibits a significant inhibitory effect on HBV DNA in the Huh7 cells, with an EC50 of 2.349 μmol/L. |
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| In vitro | Antazoline (30 microM) decreases NMDA-mediated neurotoxicity and also blocked the NMDA current with voltage-dependent and fast-reversible action (inhibition by 85+/-3% at -60 mV) |
| In vivo | Antazoline is neuroprotective in vivo in the intra-pyriform pilocarpine-induced status epilepticus model. |
Protocol (from reference)
References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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