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Technical Data
| Formula | C19H21BrN2O3S |
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| Molecular Weight | 437.35 | CAS No. | 420831-40-9 | |
| Solubility (25°C)* | In vitro | DMSO | 87 mg/mL (198.92 mM) | |
| Ethanol | 3 mg/mL (6.85 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM. | ||
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| In vitro | Treatment with AK7 increases lysine 40 (K40) acetylation of α-tubulin in neuronal cells. AK7 ameliorates alpha-synuclein toxicity in vitro[1]. |
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| In vivo | AK7 is neuroprotective in models of Parkinson's disease and prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopamine depletion and dopaminergic neuron loss in vivo. AK7 does not show beneficial effects in mouse models of amyotrophic lateral sclerosis and cerebral ischemia[1]. |
Protocol (from reference)
| Animal Study: |
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Selleck's AK 7 has been cited by 3 publications
| Caffeine improves mitochondrial dysfunction in the white matter of neonatal rats with hypoxia-ischemia through deacetylation: a proteomic analysis of lysine acetylation [ Front Mol Neurosci, 2024, 17:1394886] | PubMed: 38745725 |
| VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1 [ Int J Mol Sci, 2023, 24(5)4912] | PubMed: 36902348 |
| Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice [ Cell Rep, 2022, 40(2):111062] | PubMed: 35830807 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.