AF-353

Catalog No.S0405 Batch:S040502

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Technical Data

Formula
C14H17IN4O2
Molecular Weight 400.21 CAS No. 865305-30-2
Solubility (25°C)* In vitro DMSO 80 mg/mL (199.89 mM)
Ethanol 5 mg/mL (12.49 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
4.0mg/ml
5% DMSO 95% Corn oil
2.0mg/ml
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description AF-353 (Ro-4) is a potent, selective and orally bioavailable antagonist of P2X3 receptor and P2X2/3 receptor with pIC50 of 8.06, 8.05 and 7.41 for human P2X3, rat P2X3 and human P2X2/3, respectively.
Targets
hP2X3 [1]
(Cell-free assay)		 rP2X3 [1]
(Cell-free assay)		 hP2X2/3 [1]
(Cell-free assay)
8.06(pIC50) 8.05(pIC50) 7.41(pIC50)

Protocol (from reference)

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.