Abietic Acid

Catalog No.S5122 Batch:S512201

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Technical Data

Formula

C20H30O2
Molecular Weight 302.45 CAS No. 514-10-3
Solubility (25°C)* In vitro DMSO 60 mg/mL (198.37 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.
Targets
PPARγ [3] 5-lipoxygenase [1]
29.5 μM
In vitro Abietic acid has anti-inflammatory effects by inhibiting expression of genes involved in inflammation such as those for tumor necrosis factor-a and cyclooxygenase 2 in lipopolysaccharide-induced macrophages. Abietic acid regulates PPARγ target gene expression in RAW 264.7 macrophages and 3T3L adipocytes. It can be used for regulating lipid metabolism and atherosclelosis[2]. Abietic acid is a PPARγ ligand and that its anti-in£ammatory effect is partly due to the activation of PPARγ in stimulated macrophages. In lipopolysaccharide (LPS)-stimulated macrophages, abietic acid suppresses production of prostaglandin E2 (PGE2) in vitro and in vivo[1].
In vivo Abietic acid has an antiobesity effect in mice mediated by the regulation of adipogenesis[2].

Protocol (from reference)

Cell Assay:

[3]
  • Cell lines

    CV1 cell

  • Concentrations

    0-100μM

  • Incubation Time

    24 h

  • Method

    pM-hPPARγ, p4xUASg-tk-luc, pCMX-CBP and pRL-CMV are transfected into CV1 cells and then, 24 h after the transfection, the cells are treated with abietic acid at various concentrations for 24 h.
Animal Study:

[2]
  • Animal Models

    Male C57BL/6J mice

  • Dosages

    20 mg/kg and 40 mg/kg

  • Administration

    oral administration

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.