A-740003

Catalog No.S0826 Batch:S082601

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Technical Data

Formula

C26H30N6O3
Molecular Weight 474.55 CAS No. 861393-28-4
Solubility (25°C)* In vitro DMSO 95 mg/mL (200.18 mM)
Ethanol 1.5 mg/mL (3.16 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO Corn oil
5.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description A-740003 is a potent, selective and competitive antagonist of P2X7 receptor with IC50 of 18 nM and 40 nM for rat and human P2X7 receptors, respectively. A-740003 potently blocks agonist-evoked IL-1β release and pore formation with IC50 of 156 nM and 92 nM in differentiated human THP-1 cells.
Targets
rat P2X7 receptor [1]
(Cell-free assay)		 human P2X7 receptor [1]
(Cell-free assay)		 IL-1β pore formation [1]
(Cell-based assay)		 IL-1β release [1]
(Cell-based assay)
18 nM 40 nM 92 nM 156 nM

Protocol (from reference)

Selleck's A-740003 has been cited by 2 publications

CD39+ tumor infiltrating T cells from colorectal cancers exhibit dysfunctional phenotype [ Am J Cancer Res, 2024, 14(2):585-600] PubMed: 38455401
Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response [ Cell Rep, 2023, 42(7):112696] PubMed: 37379213

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.