ZLN005

Catalog No.S7447 Batch:S744702

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Technical Data

Formula

C17H18N2
Molecular Weight 250.34 CAS No. 49671-76-3
Solubility (25°C)* In vitro DMSO 50 mg/mL (199.72 mM)
Ethanol 12 mg/mL (47.93 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
2.5mg/ml Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
Clear solution
5% DMSO 95% Corn oil
0.625mg/ml Taking the 1 mL working solution as an example, add 50 μL of 12.5 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.
Targets
PGC-1α [1]
In vitro In L6 myotubes, ZLN005 increases expression of the PGC-1α gene and downstream genes by activation of AMP-activated protein kinase, and improves glucose uptake and fatty acid oxidation without obvious cytotoxicity. While ZLN005 does not has the same effects in rat primary hepatocytes, which suggests cell type–specificity. [1]
In vivo ZLN005 (15 mg/kg, p.o.) produces antihyperglycemia and antihyperlipidemia effects and increases insulin sensitivity in db/db mice but not lean mice. [1]

Protocol (from reference)

Animal Study:[1]
  • Animal Models

    Male C57BKS db/db and lean littermate C57BKS mice.

  • Dosages

    ~15 mg/kg

  • Administration

    p.o.

Customer Product Validation

Data from [Data independently produced by , , Exp Cell Res, 2016, 345(1):25-36.]

Data from [Data independently produced by , , Endocrine, 2016, 53(2):443-52]

Selleck's ZLN005 has been cited by 15 publications

PPAR gamma and PGC-1alpha activators protect against diabetic nephropathy by suppressing the inflammation and NF-kappaB activation [ Nephrology (Carlton), 2024, 29(12):858-872] PubMed: 39229715
ZLN005 improves the survival of polymicrobial sepsis by increasing the bacterial killing via inducing lysosomal acidification and biogenesis in phagocytes [ Front Immunol, 2023, 14:1089905] PubMed: 36820088
The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptor γ coactivator-1α [ Anim Nutr, 2022, 11:121-131] PubMed: 36204284
The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptor γ coactivator-1α [ Anim Nutr, 2022, 11:121-131] PubMed: 36204284
Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α [ Ann Transl Med, 2022, 10(22):1241] PubMed: 36544637
β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis [ Biomed Pharmacother, 2021, 144:112331] PubMed: 34673421
PGC-1ɑ Mediated-EXOG, a Specific Repair Enzyme for Mitochondrial DNA, Plays an Essential Role in the Rotenone-Induced Neurotoxicity of PC12 Cells [ J Mol Neurosci, 2021, 10.1007/s12031-020-01775-6] PubMed: 33515431
Insulin Promotes Mitochondrial Respiration and Survival through PI3K/AKT/GSK3 Pathway in Human Embryonic Stem Cells [ Stem Cell Reports, 2020, S2213-6711(20)30418-5] PubMed: 33186539
Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers [ Cancers (Basel), 2020, 12(9)E2397] PubMed: 32847042
Overexpression of Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α Protects Cardiomyocytes From Lipopolysaccharide-Induced Mitochondrial Damage and Apoptosis [ Inflammation, 2020, 10.1007/s10753-020-01255-4] PubMed: 32529514

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.