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Technical Data
| Formula | C17H18N2 |
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| Molecular Weight | 250.34 | CAS No. | 49671-76-3 | |
| Solubility (25°C)* | In vitro | DMSO | 37 mg/mL (147.79 mM) | |
| Ethanol | 2 mg/mL (7.98 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator. | |
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| In vitro | In L6 myotubes, ZLN005 increases expression of the PGC-1α gene and downstream genes by activation of AMP-activated protein kinase, and improves glucose uptake and fatty acid oxidation without obvious cytotoxicity. While ZLN005 does not has the same effects in rat primary hepatocytes, which suggests cell type–specificity. [1] | |
| In vivo | ZLN005 (15 mg/kg, p.o.) produces antihyperglycemia and antihyperlipidemia effects and increases insulin sensitivity in db/db mice but not lean mice. [1] |
Protocol (from reference)
| Animal Study:[1] |
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Customer Product Validation
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Data from [Data independently produced by , , Exp Cell Res, 2016, 345(1):25-36.]
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Data from [Data independently produced by , , Endocrine, 2016, 53(2):443-52]
Selleck's ZLN005 has been cited by 15 publications
| PPAR gamma and PGC-1alpha activators protect against diabetic nephropathy by suppressing the inflammation and NF-kappaB activation [ Nephrology (Carlton), 2024, 29(12):858-872] | PubMed: 39229715 |
| ZLN005 improves the survival of polymicrobial sepsis by increasing the bacterial killing via inducing lysosomal acidification and biogenesis in phagocytes [ Front Immunol, 2023, 14:1089905] | PubMed: 36820088 |
| The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptor γ coactivator-1α [ Anim Nutr, 2022, 11:121-131] | PubMed: 36204284 |
| The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptor γ coactivator-1α [ Anim Nutr, 2022, 11:121-131] | PubMed: 36204284 |
| Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α [ Ann Transl Med, 2022, 10(22):1241] | PubMed: 36544637 |
| β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis [ Biomed Pharmacother, 2021, 144:112331] | PubMed: 34673421 |
| PGC-1ɑ Mediated-EXOG, a Specific Repair Enzyme for Mitochondrial DNA, Plays an Essential Role in the Rotenone-Induced Neurotoxicity of PC12 Cells [ J Mol Neurosci, 2021, 10.1007/s12031-020-01775-6] | PubMed: 33515431 |
| Insulin Promotes Mitochondrial Respiration and Survival through PI3K/AKT/GSK3 Pathway in Human Embryonic Stem Cells [ Stem Cell Reports, 2020, S2213-6711(20)30418-5] | PubMed: 33186539 |
| Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers [ Cancers (Basel), 2020, 12(9)E2397] | PubMed: 32847042 |
| Overexpression of Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α Protects Cardiomyocytes From Lipopolysaccharide-Induced Mitochondrial Damage and Apoptosis [ Inflammation, 2020, 10.1007/s10753-020-01255-4] | PubMed: 32529514 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.