Tanshinone I

Catalog No.S2364 Batch:S236404

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Technical Data

Formula

C18H12O3
Molecular Weight 276.29 CAS No. 568-73-0
Solubility (25°C)* In vitro DMSO Insoluble
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
0.2mg/ml Taking the 1 mL working solution as an example, add 50 μL of 4 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
Clear solution
5% DMSO 95% corn oil
0.2mg/ml Taking the 1 mL working solution as an example, add 50 μL of 4 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.
Targets
PLA2 [1]
11 μM
In vitro Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I inhibits PGE2 formation from LPS-induced RAW macrophages (IC50 = 38 μM). However, this compound does not affect COX-2 activity or COX-2 expression. Tanshinone I is an inhibitor of type IIA human recombinant phospholipase A2 (PLA2) with IC50 of 11 μM. [1] In preliminary data, tanshinone I possesses the strongest inhibitory effect on tumor necrosis factor-α (TNF-α)-induced adhesion molecules. [2]

Protocol (from reference)

Customer Product Validation

Data from [Data independently produced by , , Oncotarget, 2015, 6(18):16031-42.]

Data from [Data independently produced by , , Biochem Pharmacol, 2018, 154:255-264]

Selleck's Tanshinone I has been cited by 10 publications

Transgelin promotes ferroptosis to inhibit the malignant progression of esophageal squamous cell carcinoma [ Int J Oncol, 2023, 63(1)76] PubMed: 37203411
Tanshinone I inhibits metastasis of cervical cancer cells by inducing BNIP3/NIX-mediated mitophagy and reprogramming mitochondrial metabolism [ Phytomedicine, 2022, 98:153958] PubMed: 35124382
Combined Treatment of Tanshinone I and Epirubicin Revealed Enhanced Inhibition of Hepatocellular Carcinoma by Targeting PI3K/AKT/HIF-1α [ Drug Des Devel Ther, 2022, 16:3197-3213] PubMed: 36158238
Tanshinone&nbsp;I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase&nbsp;1 expression [ Mol Med Rep, 2021, 23(1)40] PubMed: 33179075
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754
A network pharmacology approach to investigate the anti-inflammatory mechanism of effective ingredients from Salvia miltiorrhiza. [ Int Immunopharmacol, 2019, 10.1016/j.intimp.2019.106040] PubMed: 31818704
Tanshinone IIA inhibits cervix carcinoma stem cells migration and invasion via inhibiting YAP transcriptional activity [Qin J Biomed Pharmacother, 2018, 105:758-765] PubMed: 29909343
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis [Tian QT Biochem Pharmacol, 2018, 154:255-264] PubMed: 29753750
Tanshinone I alleviates motor and cognitive impairments via suppressing oxidative stress in the neonatal rats after hypoxic-ischemic brain damage. [ Mol Brain, 2017, 10(1):52] PubMed: 29137683
Tanshinone I inhibits tumor angiogenesis by reducing Stat3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells [Wang Y, et al. Oncotarget, 2015, 6(18):16031-42] PubMed: 26202747

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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