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Technical Data
| Formula | C19H23NO4 |
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| Molecular Weight | 329.39 | CAS No. | 115-53-7 | |
| Solubility (25°C)* | In vitro | DMSO | 65 mg/mL (197.33 mM) | |
| Water | 65 mg/mL (197.33 mM) | |||
| Ethanol | 65 mg/mL (197.33 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis. |
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| In vitro | Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis. [1] However its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. [2] Its anti-rheumatic effects are thought to be primarily mediated via release of histamine, but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved. [3] |
Protocol (from reference)
References
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Customer Product Validation
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Data from [Data independently produced by , , Int J Oncol, 2016, 48(5):2098-112]
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Data from [Data independently produced by , , Mol Pain, 2018, doi:10.1177/1744806918793232]
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Data from [Data independently produced by , , Int Immunopharmacol, 2016, 40:492-500.]
Selleck's Sinomenine has been cited by 13 publications
| Sinomenine ameliorates adjuvant-induced arthritis by inhibiting the autophagy/NETosis/inflammation axis [ Sci Rep, 2023, 13(1):3933] | PubMed: 36894604 |
| Sinomenine Inhibits Vasculogenic Mimicry and Migration of Breast Cancer Side Population Cells via Regulating miR-340-5p/SIAH2 Axis [ Biomed Res Int, 2022, 2022:4914005] | PubMed: 35309179 |
| Sinomenine exerts a neuroprotective effect on PD mouse model through inhibiting PI3K/AKT/mTOR pathway to enhance autophagy [ Int J Neurosci, 2022, 1-9] | PubMed: 35815397 |
| Sinomenine alleviates dorsal root ganglia inflammation to inhibit neuropathic pain via the p38 MAPK/CREB signalling pathway [ Eur J Pharmacol, 2021, 897:173945] | PubMed: 33596416 |
| Network Pharmacology-Based Approach to Investigate the Molecular Targets of Sinomenine for Treating Breast Cancer [ Cancer Manag Res, 2021, 13:1189-1204] | PubMed: 33603465 |
| Sinomenine-Inhibits-Non-Small-Cell-Lung-Cancer-via-Downregulation-of-Hexokinases-II-Mediated-Aerobic-Glycolysis. [ Onco-Targets-Ther, 2020, 16;13:3209-3221] | PubMed: 32368080 |
| Sinomenine inhibits hypoxia induced breast cancer side population cells metastasis by PI3K/Akt/mTOR pathway [ Bioorg Med Chem, 2020, 31:115986] | PubMed: 33412412 |
| An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] | PubMed: 30900754 |
| Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis. [ Int J Biol Sci, 2019, 15(11):2497-2508] | PubMed: 31595166 |
| Sinomenine mitigates collagen-induced arthritis mice by inhibiting angiogenesis. [ Biomed Pharmacother, 2019, 113:108759] | PubMed: 30856539 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.