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Technical Data
| Formula | C25H22O10 |
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| Molecular Weight | 482.44 | CAS No. | 65666-07-1 | |
| Solubility (25°C)* | In vitro | DMSO | 96 mg/mL (198.98 mM) | |
| Ethanol | 1 mg/mL (2.07 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer. |
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| In vitro | Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer. [1] The mechanisms of action of silymarin involve different biochemical events, such as the stimulation of the synthetic rate of ribosomal RNA (rRNA) species through stimulation of polymerase I and rRNA transcription, protecting the cell membrane from radical-induced damage and blockage of the uptake of toxins such as alpha-amanitin. [2] Silymarin can also provide substantial protection against different stages of UVB-induced carcinogenesis, possibly via its strong antioxidant properties. sup>[3] |
| In vivo | LD50: Mice 391.4mg/kg (i.v.); Rats 370.1mg/kg (i.v.); Rabbits 142.3mg/kg (i.v.) sup>[4] |
Protocol (from reference)
References
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Customer Product Validation
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, , Pharm Biol, 2016, 8:1-6.
Selleck's Silymarin has been cited by 3 publications
| FİTNESS MERKEZİNE GİDEN BİREYLERİN SAĞLIKLI BESLENMEYE İLİŞKİN TUTUMLARININ İNCELENMESİ [ Research gate, 2023, ] | PubMed: none |
| Silymarin improved diet-induced liver damage and insulin resistance by decreasing inflammation in mice [Guo Y, et al. Pharm Biol, 2016, 10.1080/13880209.2016.1199042] | PubMed: 27387273 |
| Silymarin attenuated hepatic steatosis through regulation of lipid metabolism and oxidative stress in a mouse model of nonalcoholic fatty liver disease (NAFLD). [ Am J Transl Res, 2016, 8(2):1073-81] | PubMed: 27158393 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.