Quercetin

Catalog No.S2391 Batch:S239106

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Technical Data

Formula

C15H10O7
Molecular Weight 302.24 CAS No. 117-39-5
Solubility (25°C)* In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 20 mg/mL (66.17 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO Corn oil
3.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 60 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)		 PI3Kδ [1]
(Cell-free assay)		 View More
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1]

Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]
In vivo

Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3]

LD50: >3000mg/kg (i.g.) [4]

Protocol (from reference)

Cell Assay:

[5]
  • Cell lines

    Sertoli cells

  • Concentrations

    0.1 μM

  • Incubation Time

    24 h

  • Method

    Cells were treated with various concentrations of drug for 24 h.

Customer Product Validation

Data independently produced by Dr. Zhang of Tianjin Medical University, 2011

Selleck's Quercetin has been cited by 45 publications

Increased PTCHD4 expression via m6A modification of PTCHD4 mRNA promotes senescent cell survival [ Nucleic Acids Res, 2024, gkae322] PubMed: 38721764
Downregulated SPESP1-driven fibroblast senescence decreases wound healing in aged mice [ Clin Transl Med, 2024, 14(5):e1660] PubMed: 38764260
FGF receptors mediate cellular senescence in the cystic fibrosis airway epithelium [ JCI Insight, 2024, 9(15)e174888] PubMed: 38916962
Investigating the potential mechanism and therapeutic effects of SLXG for cholesterol gallstone treatment [ Phytomedicine, 2024, 132:155886] PubMed: 39059092
Quercetin-induced pyroptosis in colon cancer through NEK7-mediated NLRP3 inflammasome-GSDMD signaling pathway activation [ Am J Cancer Res, 2024, 14(3):934-958] PubMed: 38590424
The p21+ perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regeneration [ Toxicology, 2024, 504:153804] PubMed: 38614205
Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts [ bioRxiv, 2024, 2024.05.10.593637] PubMed: 38798365
Cellular senescence primes liver fibrosis regression through Notch-EZH2 [ MedComm (2020), 2023, 4(5):e346] PubMed: 37614965
Cellular senescence primes liver fibrosis regression through Notch-EZH2 [ MedComm -2020), 2023, 4(5):e346] PubMed: 37614965
Treatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice [ Aging Cell, 2023, e13771.] PubMed: 36704839

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.