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Formula | C21H20O9 |
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Molecular Weight | 416.38 | CAS No. | 3681-99-0 | |
Solubility (25°C)* | In vitro | DMSO | 86 mg/mL (206.54 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. |
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In vitro | Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. [1] Pueraria is employed clinically to treat cardiovascular diseases in China. [2] Another study showed that puerarin also possessed anti-cancer properties. Puerarin at 25 μM dose-dependently reduces HT-29 cellular growth with an increase of bax and decreases of c-myc and bcl-2. [3] |
In vivo | In hypercholesterolmic diet plus administration of puerarin (300 mg/kg/day, p.o.) rats, Puerarin markedly attenuated the increased total cholesterol induced by hypercholesterolmic diet in both serum and liver. [2] LD50: Mice 738mg/kg (i.v.) [4] |
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Puerarin inhibits NHE1 activity by interfering with the p38 pathway and attenuates mitochondrial damage induced by myocardial calcium overload in heart failure rats [ Acta Biochim Biophys Sin (Shanghai), 2024, 56(2):270-279] | PubMed: 38282474 |
Puerarin Prevents Cadmium-Induced Neuronal Injury by Alleviating Autophagic Dysfunction in Rat Cerebral Cortical Neurons [ Int J Mol Sci, 2023, 24(9)8328] | PubMed: 37176033 |
Puerarin alleviates cadmium-induced rat neurocyte injury by alleviating Nrf2-mediated oxidative stress and inhibiting mitochondrial unfolded protein response [ Ecotoxicol Environ Saf, 2022, 247:114239] | PubMed: 36326556 |
Puerarin attenuates cisplatin-induced apoptosis of hair cells through the mitochondrial apoptotic pathway [ Biochim Biophys Acta Mol Cell Res, 2022, S0167-4889(21)00262-7] | PubMed: 35032475 |
Puerarin Restores Autophagosome-Lysosome Fusion to Alleviate Cadmium-Induced Autophagy Blockade via Restoring the Expression of Rab7 in Hepatocytes [ Front Pharmacol, 2021, 12:632825] | PubMed: 33935722 |
Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors [ Int J Mol Sci, 2020, 21(14):5025] | PubMed: 32708687 |
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] | PubMed: 30900754 |
Puerarin Decreases Collagen Secretion in AngII-Induced Atrial Fibroblasts Through Inhibiting Autophagy Via the JNK-Akt-mTOR Signaling Pathway. [ J Cardiovasc Pharmacol, 2019, 73(6):373-382] | PubMed: 31162246 |
Colloidal Aggregation and the in vitro Activity of Traditional Chinese Medicines. [Duan D, et al. ACS Chem Biol, 2015, 10.1021/cb5009487] | PubMed: 25606714 |
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