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Technical Data
| Formula | K+I- |
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| Molecular Weight | 166 | CAS No. | 7681-11-0 | |
| Solubility (25°C)* | In vitro | DMSO | 33 mg/mL (198.79 mM) | |
| Water | 33 mg/mL (198.79 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Potassium Iodide is used to treat overactive thyroid and to protect the thyroid gland from the effects of radiation from inhaled or swallowed radioactive iodine. |
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| In vitro | Iodine induces abnormal morphologic changes of cells, inhibited cell proliferation, and increases apoptosis rate in rat aorta endothelial cells. Iodine also reduces the activity of SOD, GSH-Px, and concentrations of GSH and increases the concentrations of MDA and protein carbonyl in a dose-dependent manner. Excess iodine decreased the activity of eNOS and increased the activity of iNOS and the expression of ICAM-1 and VCAM-1 in culture medium. Excess iodine exposure increases oxidative stress, causes damage of vascular endothelial cells, and altered the expression of adhesion factors and the activity of NOS. [1] Potassium iodide increases avidity of some immune reactions including C-mediated cell lysis mediated by altered access of C-binding receptors. [2] Potassium iodide (≥50 mM) increases lipid peroxidation in concentration-dependent manner. Potassium iodide (25 mM) reduces Fenton reaction-induced lipid peroxidation. [3] Potassium iodide is able to eliminate E faecalis from bovine root dentin when used with a 15-minute contact time. [4] |
| In vivo | Potassium Iodide decreases Schiff's bases (SB) concentrations in liver and lung homogenates after the administration of PTU but, unexpectedly, the level of SB increases in kidney homogenates of Wistar rats. [5] |
Protocol (from reference)
References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.