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Technical Data
| Formula | C21H22O8 |
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| Molecular Weight | 402.39 | CAS No. | 478-01-3 | |
| Solubility (25°C)* | In vitro | DMSO | 80 mg/mL (198.81 mM) | |
| Ethanol | 5 mg/mL (12.42 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. | |
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| In vitro | Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. Nobiletin, a polymethoxyflavonoid, is identified as an inhibitor of both NO and O 2- generation. Nobiletin significantly inhibites two skin inflammation induced by double TPA application. It also suppresses the expression of cyclooxygenase-2 and inducible NO synthase proteins and prostaglandin E2 release. [1] Nobiletin inhibites the tumor-invasive activity of human fibrosarcoma HT-1080 cells in the Matrigel model, not only by suppressing the expression of MMPs but also augmenting TIMP-1 production through interfering the phosphatidylinositol 3-kinase pathway (PI3-K). [2] Nobiletin may also prevent atherosclerosis at the level of the vascular wall by inhibiting macrophage foam-cell formation. [3] | |
| In vivo | LD50: 780mg/kg (i.g.). [4] |
Protocol (from reference)
References
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Customer Product Validation
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, , Nutr Metab (Lond), 2015, 12:23.
Selleck's Nobiletin has been cited by 15 publications
| Flavonoids regulate LDLR through different mechanisms tied to their specific structures [ J Lipid Res, 2024, S0022-2275(24)00044-0] | PubMed: 38556050 |
| The Circadian Nobiletin-ROR Axis Suppresses Adipogenic Differentiation and IκBα/NF-κB Signaling in Adipocytes [ Nutrients, 2023, 15(18)3919] | PubMed: 37764703 |
| Nobiletin, a NF-κB signaling antagonist, promotes BMP-induced bone formation [ FASEB Bioadv, 2023, 5(2):62-70] | PubMed: 36816515 |
| ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer [ Cell Death Dis, 2022, 13(4):374] | PubMed: 35440077 |
| The clock modulator Nobiletin mitigates astrogliosis-associated neuroinflammation and disease hallmarks in an Alzheimer's disease model [ FASEB J, 2022, 36(3):e22186] | PubMed: 35120261 |
| Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial dysfunction [ J Nutr Biochem, 2021, S0955-2863(21)00308-9] | PubMed: 34695558 |
| Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma [ Cancer Biol Med, 2021, 18(1):227-244] | PubMed: 33628597 |
| Cardiolipin Synthesis in Skeletal Muscle Is Rhythmic and Modifiable by Age and Diet [ Oxid Med Cell Longev, 2020, 2020:5304768] | PubMed: 32617138 |
| Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors [ Int J Mol Sci, 2020, 21(14):5025] | PubMed: 32708687 |
| Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge. [ Nat Commun, 2019, 10(1):3923] | PubMed: 31462679 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.