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Technical Data
| Formula | C28H34O15 |
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| Molecular Weight | 610.56 | CAS No. | 13241-33-3 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (163.78 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Neohesperidin (NSC 31048), a flavanone glycoside found in citrus fruits, is an antioxidant agent. |
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| In vitro | Neohesperidin, a flavanone glycoside found in citrus fruits, is an antioxidant agent. Neohesperidin is an antioxidant agent with an IC50 of 22.31 μg/ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay. Neohesperidin (50 mg/kg) significantly inhibits HCl/ethanol-induced gastric lesions, and increases the mucus content. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreases the volume of gastric secretion and gastric acid output, and increases the pH. [1] In addition, Neohesperidin inhibits the growth of Caco-2, CEM/ADR5000 and CCRF-CEM leukaemia cells with IC50 of 0.17, 0.17 and 0.12 mM, respectively. [2] |
Protocol (from reference)
References
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Selleck's Neohesperidin has been cited by 6 publications
| Neohesperidin protects against colitis-associated colorectal cancer in mice via suppression of the NF-κB/p65 and MAPK pathways [ J Nutr Biochem, 2024, 136:109804] | PubMed: 39547268 |
| Connexin43 is associated with the progression of clear cell renal carcinoma and is regulated by tangeretin to sygergize with tyrosine kinase inhibitors [ Transl Oncol, 2023, 35:101712] | PubMed: 37354638 |
| Biomolecular interactions with nanoparticles: Applications for COVID-19 [ Curr Opin Colloid Interface Sci, 2021, 101461] | PubMed: 33907504 |
| An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] | PubMed: 30900754 |
| Neohesperidin inhibits TGF-β1/Smad3 signaling and alleviates bleomycin-induced pulmonary fibrosis in mice [ Eur J Pharmacol, 2019, 864:172712] | PubMed: 31586469 |
| A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells. [ Sci Rep, 2017, 7(1):9873] | PubMed: 28852176 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.