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Technical Data
| Formula | C17H20O6 |
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| Molecular Weight | 320.34 | CAS No. | 24280-93-1 | |
| Solubility (25°C)* | In vitro | DMSO | 64 mg/mL (199.78 mM) | |
| Ethanol | 18 mg/mL (56.19 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation. | |
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| In vitro | Mycophenolic acid inhibits inosine-5'-monophosphate dehydrogenase (IMPDH) by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule. [1] Mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase, in nanomolar concentrations blocks proliferative responses of cultured human, mouse and rat T lymphocytes and B lymphocytes to mitogens or in mixed lymphocyte reactions. Mycophenolic acid (MPA) suppresses mixed lymphocyte reactions when added 3 days after their initiation. Mycophenolic acid also inhibits antibody formation by polyclonally activated human B lymphocytes. Mycophenolic acid is an immunosuppressive agent reversibly inhibiting proliferation of T and B lymphocytes and antibody formation, with a profile of activity different from that of other immunosuppressive drugs. [2] Mycophenolic acid inhibits the formation of antibodies to sheep erythrocytes. Mycophenolic acid also suppresses, in a dose-related manner, the generation of cytotoxic T-lymphocytes against allogeneic cells in mice and prevents the elimination of allogeneic cells. [3] Mycophenolic acid induces apoptosis and cell death in a large proportion of activated CD4+ T cells. [4] | |
| In vivo | Mycophenolic acid has lymphocyte-selective anti-proliferative effects in mice and can inhibit both cell-mediated and humoral immune responses without major side effects. [3] |
Protocol (from reference)
References
Selleck's Mycophenolic acid has been cited by 10 publications
| Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer [ Cancer Cell, 2023, 41(1):124-138.e6] | PubMed: 36563680 |
| Multiparametric Profiling of Neutrophil Function via a High-Throughput Flow Cytometry-Based Assay [ Cells, 2023, 12(5)743] | PubMed: 36899878 |
| Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications [ Nat Commun, 2021, 12(1):1618] | PubMed: 33712622 |
| Application of a newly-developed cynomolgus macaque BiTE-mediated cytotoxic T-lymphocyte activity assay to various immunomodulatory agents in vitro [ J Immunotoxicol, 2021, 18(1):154-162] | PubMed: 34714999 |
| High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against Arenaviruses and SARS-CoV-2 [ ACS Infect Dis, 2020, acsinfecdis.0c00486] | PubMed: 33183004 |
| Identification of Modulators of HIV-1 Proviral Transcription from a Library of FDA-Approved Pharmaceuticals [ Viruses, 2020, 12(10)E1067] | PubMed: 32977702 |
| Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers. [ Cell Metab, 2018, 28(3):369-382] | PubMed: 30043754 |
| Zika virus cell tropism in the developing human brain and inhibition by azithromycin. [ Proc Natl Acad Sci U S A, 2016, 113(50):14408-14413] | PubMed: 27911847 |
| Btk inhibition treats TLR7/IFN driven murine lupus [Bender AT Clin Immunol, 2016, 164:65-77] | PubMed: 26821304 |
| A sensitive virus yield assay for evaluation of Antivirals against Zika Virus. [Goebel S, et al. J Virol Methods, 2016, 238:13-20] | PubMed: 27678028 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.