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Formula | C18H18O2 |
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Molecular Weight | 266.33 | CAS No. | 528-43-8 | ||||||||
Solubility (25°C)* | In vitro | DMSO | 53 mg/mL (199.0 mM) | ||||||||
Ethanol | 53 mg/mL (199.0 mM) | ||||||||||
Water | Insoluble | ||||||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-κB activation. | |
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In vitro | Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. [1] Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml. [2] |
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In vivo | LD50: Mice 2200mg/kg (i.g.). [3] |
Data from [Data independently produced by , , Inflamm Res, 2016, 65(1):81-93]
FGF7/FGFR2-JunB signalling counteracts the effect of progesterone in luminal breast cancer [ Mol Oncol, 2022, 16(15):2823-2842] | PubMed: 35726195 |
Magnolol limits NFκB-dependent inflammation by targeting PPARγ relieving retinal ischemia/reperfusion injury [ Int Immunopharmacol, 2022, 112:109242] | PubMed: 36152538 |
Maternal magnolol supplementation alters placental morphology, promotes placental angiogenesis during mid-gestation and improves offspring growth in a pregnant mouse model [ Reprod Biol, 2021, 21(4):100567] | PubMed: 34653815 |
Upregulation of HIF1-α via an NF-κB/COX2 pathway confers proliferative dominance of HER2-negative ductal carcinoma in situ cells in response to inflammatory stimuli [ Neoplasia, 2020, 22(11):576-589] | PubMed: 32980776 |
Thin-layer chromatographic quantification of magnolol and honokiol in dietary supplements and selected biological properties of these preparations [ J Chromatogr A, 2020, 1625:461230] | PubMed: 32709311 |
Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator [Li Z Micromachines, 2018, 9(6)] | PubMed: 30424207 |
Anti-angiogenic and anti-inflammatory effect of Magnolol in the oxygen-induced retinopathy model. [Yang B, et al. Inflamm Res, 2016, 65(1):81-93] | PubMed: 26547789 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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