Magnolol

Catalog No.S2321 Batch:S232102

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Technical Data

Formula

C18H18O2
Molecular Weight 266.33 CAS No. 528-43-8
Solubility (25°C)* In vitro DMSO 53 mg/mL (199.0 mM)
Ethanol 53 mg/mL (199.0 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
0.3mg/ml Taking the 1 mL working solution as an example, add 50 μL of 6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
2.65mg/ml Taking the 1 mL working solution as an example, add 50 μL of 53 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-κB activation.
Targets
NF-κB [4]
In vitro

Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. [1] Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml. [2]
In vivo

LD50: Mice 2200mg/kg (i.g.). [3]

Protocol (from reference)

Customer Product Validation

Data from [Data independently produced by , , Inflamm Res, 2016, 65(1):81-93]

Selleck's Magnolol has been cited by 7 publications

FGF7/FGFR2-JunB signalling counteracts the effect of progesterone in luminal breast cancer [ Mol Oncol, 2022, 16(15):2823-2842] PubMed: 35726195
Magnolol limits NFκB-dependent inflammation by targeting PPARγ relieving retinal ischemia/reperfusion injury [ Int Immunopharmacol, 2022, 112:109242] PubMed: 36152538
Maternal magnolol supplementation alters placental morphology, promotes placental angiogenesis during mid-gestation and improves offspring growth in a pregnant mouse model [ Reprod Biol, 2021, 21(4):100567] PubMed: 34653815
Upregulation of HIF1-α via an NF-κB/COX2 pathway confers proliferative dominance of HER2-negative ductal carcinoma in situ cells in response to inflammatory stimuli [ Neoplasia, 2020, 22(11):576-589] PubMed: 32980776
Thin-layer chromatographic quantification of magnolol and honokiol in dietary supplements and selected biological properties of these preparations [ J Chromatogr A, 2020, 1625:461230] PubMed: 32709311
Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator [Li Z Micromachines, 2018, 9(6)] PubMed: 30424207
Anti-angiogenic and anti-inflammatory effect of Magnolol in the oxygen-induced retinopathy model. [Yang B, et al. Inflamm Res, 2016, 65(1):81-93] PubMed: 26547789

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.