Ivermectin

Catalog No.S1351 Batch:S135102

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Technical Data

Formula

C48H74O14

Molecular Weight 875.09 CAS No. 70288-86-7
Solubility (25°C)* In vitro DMSO 175 mg/mL (199.97 mM)
Ethanol 28 mg/mL (31.99 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.
Targets
chloride channel [3]
In vitro

Ivermectin has potent antiviral activity towards both HIV-1 anddengue virus, both of which are strongly reliant on importin α/β nuclear import, with respect to the HIV-1 integrase and NS5 (non-structural protein 5) polymerase proteins respectively. [1] Ivermectin binds to a novel site on the GABAA receptor and allosterically enhances the affinity of the GABA binding site in mouse hippocampal embryonic neurons. [2] Ivermectin disrupts neurotransmission processes regulated by GluCl activity by binding to nematode glutamate-gated chloride channels (GluCls). Ivermectin decreases the amount of protein released from microfilariae. [3]

In vivo

Ivermectin (1.25-10 mg/kg, intraperitoneal) significantly reduces 24-h alcohol consumption and intermittent limited access (4-hours) binge drinking, and operant alcohol self-administration (1-h). Ivermectin also produces a significant reduction in 24-h saccharin consumption, but does not alter operant sucrose self-administration. [4] Ivermectin improves mouse survival rate induced by a lethal dose of LPS. Ivermectin significantly decreases the production of TNF-alpha, IL-1ss and IL-6 in vivo and in vitro. Ivermectin suppresses NF-kB translocation induced by LPS. [5]

Protocol (from reference)

Selleck's Ivermectin has been cited by 17 publications

The Dual-Targeted Fusion Inhibitor Clofazimine Binds to the S2 Segment of the SARS-CoV-2 Spike Protein [ Viruses, 2024, 16(4)640] PubMed: 38675980
The CHARGE syndrome-associated protein FAM172A controls AGO2 nuclear import [ Life Sci Alliance, 2023, 6(8)e202302133] PubMed: 37221016
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization [ Cell Rep Methods, 2023, 3(10):100599] PubMed: 37797618
Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction [ Front Pharmacol, 2022, 13:934746] PubMed: 36091811
The Antineoplastic Effect of Carboplatin Is Potentiated by Combination with Pitavastatin or Metformin in a Chemoresistant High-Grade Serous Carcinoma Cell Line [ Int J Mol Sci, 2022, 24(1)97] PubMed: 36613537
Pitavastatin and Ivermectin Enhance the Efficacy of Paclitaxel in Chemoresistant High-Grade Serous Carcinoma [ Cancers (Basel), 2022, 14(18)4357] PubMed: 36139522
Synergistic drug combinations designed to fully suppress SARS-CoV-2 in the lung of COVID-19 patients [ PLoS One, 2022, 17(11):e0276751] PubMed: 36355808
Repurposing Ivermectin to augment chemotherapy's efficacy in osteosarcoma [ Hum Exp Toxicol, 2022, 41:9603271221143693] PubMed: 36503300
Nucleocytoplasmic Shuttling of Porcine Parvovirus NS1 Protein Mediated by the CRM1 Nuclear Export Pathway and the Importin α/β Nuclear Import Pathway [ J Virol, 2021, JVI0148121] PubMed: 34643426
Ivermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway [ BMC Cancer, 2021, 21(1):1307] PubMed: 34876051

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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