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Technical Data
| Formula | C15H12O4 |
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| Molecular Weight | 256.25 | CAS No. | 961-29-5 | |
| Solubility (25°C)* | In vitro | DMSO | 51 mg/mL (199.02 mM) | |
| Ethanol | 26 mg/mL (101.46 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits aldose reductase with an IC50 of 320 nM. | ||
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| In vitro | Isoliquiritigenin may be effective in preventing diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. [1] Isoliquiritigenin may also serve as a skin-lightening agent by inhibiting mono- and diphenolase tyrosinase activities with an IC50 of 8.1 μM. [2] Isoliquiritigenin induces cell cycle arrest and cell growth inhibition in DU145 and LNCaP prostate cancer cell lines. [3] Isoliquiritigenin induces apoptosis of human gastric cancer MGC-803 cells through increasing the intracellular free calcium concentration and decreasing the mitochondrial transmembrane potential (Deltapsi(m)). [4] | ||
| In vivo | LD50: Mice >6g/kg (i.g.) [5] |
Protocol (from reference)
References
Customer Product Validation
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Data from [Data independently produced by J Biol Chem, 2014, 289(52), 35839-48]
Selleck's Isoliquiritigenin has been cited by 9 publications
| High-Throughput Drug Library Screening in Primary KMT2A-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling [ Biomedicines, 2022, 10(3)638] | PubMed: 35327440 |
| Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer [ Cancer Res, 2021, 81(16):4257-4274] | PubMed: 34185677 |
| Isoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest. [ Biomed Res Int, 2020, 2020:9259852] | PubMed: 32190688 |
| Integrating Differential Gene Expression Analysis with Perturbagen-Response Signatures May Identify Novel Therapies for Thyroid-Associated Orbitopathy [ Transl Vis Sci Technol, 2020, 9(9):39] | PubMed: 32908802 |
| An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] | PubMed: 30900754 |
| Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis. [ Int J Biol Sci, 2019, 15(11):2497-2508] | PubMed: 31595166 |
| Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3. [ Proc Natl Acad Sci U S A, 2018, 115(42):E9869-E9878] | PubMed: 30275324 |
| Cell-based assay system for high-throughput screening of anti-photo-aging agents in fibroblast transfectants. [Lee S, et al. Cytotechnology, 2016, 68(4):1633-40] | PubMed: 26281901 |
| Isoliquiritigenin Induces Apoptosis and Inhibits Xenograft Tumor Growth of Human Lung Cancer Cells by Targeting Both Wildtype and L858R/T790M Mutant EGFR. [Jung SK, et al. J Biol Chem, 2014, 10.1074/jbc.M114.585513] | PubMed: 25368326 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.