Ibudilast

Catalog No.S4837 Batch:S483703

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Technical Data

Formula

C14H18N2O
Molecular Weight 230.31 CAS No. 50847-11-5
Solubility (25°C)* In vitro DMSO 46 mg/mL (199.73 mM)
Ethanol 46 mg/mL (199.73 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
4.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 80 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
4.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 80 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Ibudilast (KC-404, AV411, MN166) is a relatively non-selective phosphodiesterase inhibitor with anti-inflammatory and neuroprotective activities.
Targets
PDE4 [1]
(Bovine aortic EC)		 PDE2 [1]
(Bovine aortic EC)		 PDE5 [1]
(Human platelets)
0.08 μM 0.11 μM 2.2 μM
In vitro Ibudilast suppressses pro-inflammatory cytokines (IL-6, IL-1β, TNF-α), toll-like receptor 4 blockade (TLR-4); inhibits a macrophage migration inhibitory factor (MIF), upregulates the anti‑inflammatory cytokine (IL-10) and promotes neurotrophic factors (GDNF, NGF, NT‑4)[1].
In vivo Ibudilast crosses the blood-brain barrier and has a good tolerance in vivo. It inhibits platelet aggregation, improves cerebral blood flow and attenuates allergic reactions in clinical applications. In an animal model of encephalomyelitis, Ibudilast significantly attenuates inflammatory cell infiltration in the lumbar spinal cord. After oral administration, it is well absorbed and metabolized in the liver mainly to diOH-ibudilast, which has similar or even stronger pharmacological effects[1].

Protocol (from reference)

Animal Study:

[2]
  • Animal Models

    A gerbil model of carotid artery thrombosis

  • Dosages

    0.3 and 1.0 mg/kg

  • Administration

    i.v.

Selleck's Ibudilast has been cited by 3 publications

Immunotherapeutic treatment of inflammation in mice exposed to methamphetamine [ Front Psychiatry, 2023, 14:1259041] PubMed: 38025429
Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia [ Neuron, 2020, 108(5):876-886.e4] PubMed: 33108748
Examination of the Role of Neuroimmune Signaling in Drug Addiction [ CU Scholar, 2019, N/A] PubMed: N/A

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.