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Technical Data
| Formula | C14H18N2O |
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| Molecular Weight | 230.31 | CAS No. | 50847-11-5 | |
| Solubility (25°C)* | In vitro | DMSO | 46 mg/mL (199.73 mM) | |
| Ethanol | 46 mg/mL (199.73 mM) | |||
| Water | 30 mg/mL (130.25 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Ibudilast (KC-404, AV411, MN166) is a relatively non-selective phosphodiesterase inhibitor with anti-inflammatory and neuroprotective activities. | ||||||
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| Targets |
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| In vitro | Ibudilast suppressses pro-inflammatory cytokines (IL-6, IL-1β, TNF-α), toll-like receptor 4 blockade (TLR-4); inhibits a macrophage migration inhibitory factor (MIF), upregulates the anti‑inflammatory cytokine (IL-10) and promotes neurotrophic factors (GDNF, NGF, NT‑4)[1]. | ||||||
| In vivo | Ibudilast crosses the blood-brain barrier and has a good tolerance in vivo. It inhibits platelet aggregation, improves cerebral blood flow and attenuates allergic reactions in clinical applications. In an animal model of encephalomyelitis, Ibudilast significantly attenuates inflammatory cell infiltration in the lumbar spinal cord. After oral administration, it is well absorbed and metabolized in the liver mainly to diOH-ibudilast, which has similar or even stronger pharmacological effects[1]. |
Protocol (from reference)
| Animal Study: |
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References
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Selleck's Ibudilast has been cited by 3 publications
| Immunotherapeutic treatment of inflammation in mice exposed to methamphetamine [ Front Psychiatry, 2023, 14:1259041] | PubMed: 38025429 |
| Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia [ Neuron, 2020, 108(5):876-886.e4] | PubMed: 33108748 |
| Examination of the Role of Neuroimmune Signaling in Drug Addiction [ CU Scholar, 2019, N/A] | PubMed: N/A |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.