Glycyrrhizin (NSC 167409)

Catalog No.S2302 Batch:S230206

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Technical Data

Formula

C42H62O16
Molecular Weight 822.93 CAS No. 1405-86-3
Solubility (25°C)* In vitro DMSO 100 mg/mL (121.51 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 40% PEG 300 10%Tween80 45%ddH2O
6.25mg/ml Taking the 1 mL working solution as an example, add 50 μL of 125 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 100 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 450 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
Clear solution
5% DMSO 95% Corn oil
0.4mg/ml Taking the 1 mL working solution as an example, add 50 μL of 8 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).
Targets
11 beta-hydroxysteroid dehydrogenase [1] HMGB1 [2] MAO [4]
(Cell-free)
0.16 μM
In vitro

Glycyrrhizin inhibits monoamine oxidase (MAO) with the IC50 value of 0.16 μM[4].
In vivo

Glycyrrhizin increases the levels of monoamines like epinephrine and dopamine in brains of mice[3].

Protocol (from reference)

Animal Study:

[3]
  • Animal Models

    Swiss albino mice

  • Dosages

    1.5, 3.0 and 6.0 mg/kg

  • Administration

    i.p.

Customer Product Validation

Data from [Data independently produced by , , DNA Cell Biol, 2017, 36(1):67-76]

Selleck's Glycyrrhizin (NSC 167409) has been cited by 36 publications

Cytosolic Hmgb1 accumulation in mesangial cells aggravates diabetic kidney disease progression via NFκB signaling pathway [ Cell Mol Life Sci, 2024, 81(1):408] PubMed: 39287634
Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis [ Ecotoxicol Environ Saf, 2024, 272:116068] PubMed: 38330871
HMGB1-Mediated Cell Death-A Crucial Element in Post-Hepatectomy Liver Failure [ Int J Mol Sci, 2024, 25(13)7150] PubMed: 39000266
The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization [ Front Immunol, 2023, 14:1024706] PubMed: 36761729
The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization [ Front Immunol, 2023, 10.3389/fimmu.2023.1024706] PubMed: 36761729
Glycyrrhizin mitigates acute lung injury by inhibiting the NLRP3 inflammasome in vitro and in vivo [ J Ethnopharmacol, 2023, 303:115948] PubMed: 36423713
Connexin43 is associated with the progression of clear cell renal carcinoma and is regulated by tangeretin to sygergize with tyrosine kinase inhibitors [ Transl Oncol, 2023, 35:101712] PubMed: 37354638
Effects of HMGB1/RAGE/cathespin B inhibitors on alleviating hippocampal injury by regulating microglial pyroptosis and caspase activation in neonatal hypoxic-ischemic brain damage [ J Neurochem, 2023, 167(3):410-426] PubMed: 37753942
Glycyrrhizin Attenuates Hypoxic-Ischemic Brain Damage by Inhibiting Ferroptosis and Neuroinflammation in Neonatal Rats via the HMGB1/GPX4 Pathway [ Oxid Med Cell Longev, 2022, 2022:8438528] PubMed: 35432719
Inhibition of HMGB1/TLR4 Signaling Pathway by Digitoflavone: A Potential Therapeutic Role in Alcohol-Associated Liver Disease [ J Agric Food Chem, 2022, 70(9):2968-2983] PubMed: 35212223

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.