Glycyrrhizin (NSC 167409)

Catalog No.S2302 Batch:S230203

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Technical Data

Formula

C42H62O16
Molecular Weight 822.93 CAS No. 1405-86-3
Solubility (25°C)* In vitro DMSO 100 mg/mL (121.51 mM)
Ethanol 100 mg/mL (121.51 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).
Targets
11 beta-hydroxysteroid dehydrogenase [1] HMGB1 [2] MAO [4]
(Cell-free)
0.16 μM
In vitro

Glycyrrhizin inhibits monoamine oxidase (MAO) with the IC50 value of 0.16 μM[4].
In vivo

Glycyrrhizin increases the levels of monoamines like epinephrine and dopamine in brains of mice[3].

Protocol (from reference)

Animal Study:

[3]
  • Animal Models

    Swiss albino mice

  • Dosages

    1.5, 3.0 and 6.0 mg/kg

  • Administration

    i.p.

Customer Product Validation

Data from [Data independently produced by , , DNA Cell Biol, 2017, 36(1):67-76]

Selleck's Glycyrrhizin (NSC 167409) has been cited by 41 publications

EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis [ Chin Med J (Engl), 2025, 138(1):79-92] PubMed: 39704001
Cytosolic Hmgb1 accumulation in mesangial cells aggravates diabetic kidney disease progression via NFκB signaling pathway [ Cell Mol Life Sci, 2024, 81(1):408] PubMed: 39287634
Targeting acetylated high mobility group box 1 protein (HMGB1) and toll-like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose-fed rats [ Br J Pharmacol, 2024, 10.1111/bph.17402] PubMed: 39627019
Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis [ Ecotoxicol Environ Saf, 2024, 272:116068] PubMed: 38330871
HMGB1-Mediated Cell Death-A Crucial Element in Post-Hepatectomy Liver Failure [ Int J Mol Sci, 2024, 25(13)7150] PubMed: 39000266
Glycyrrhizin ameliorates colorectal cancer progression by regulating NHEJ pathway through inhibiting HMGB1-induced DNA damage response [ Sci Rep, 2024, 14(1):24948] PubMed: 39438689
NETs exacerbate placental inflammation and injury through high mobility group protein B1 during preeclampsia [ Placenta, 2024, 159:131-139] PubMed: 39718052
Glycyrrhizin inhibits LPS-induced neutrophil-like release of NETs [ Am J Transl Res, 2024, 16(10):5507-5515] PubMed: 39544807
The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization [ Front Immunol, 2023, 14:1024706] PubMed: 36761729
The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization [ Front Immunol, 2023, 10.3389/fimmu.2023.1024706] PubMed: 36761729

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.