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Formula | C15H10O6 |
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Molecular Weight | 286.24 | CAS No. | 528-48-3 | ||||
Solubility (25°C)* | In vitro | DMSO | 57 mg/mL (199.13 mM) | ||||
Ethanol | 14 mg/mL (48.91 mM) | ||||||
Water | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins. | |
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Targets |
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In vitro | Fisetin selectively kills SPiDER-β-Gal positive senescence neural cells in vitro.[2] |
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In vivo | Oral administration of fisetin, a senolytic drug, reduces the number of senescent neural cells observed, the SASP expression level, and depressive behavior in MRL/lpr mice.[2] |
Cell Assay: |
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Animal Study: |
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Data from [Data independently produced by , , Alcohol Clin Exp Res, 2016, 40(10):2076-2084.]
TAGLN2 induces resistance signature ISGs by activating AKT-YBX1 signal with dual pathways and mediates the IFN-related DNA damage resistance in gastric cancer [ Cell Death Dis, 2024, 15(8):608] | PubMed: 39168971 |
Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL-F/NL-F mice [ Geroscience, 2024, 10.1007/s11357-024-01308-8] | PubMed: 39120687 |
Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts [ bioRxiv, 2024, 2024.05.10.593637] | PubMed: 38798365 |
Clearance of defective muscle stem cells by senolytics restores myogenesis in myotonic dystrophy type 1 [ Nat Commun, 2023, 14(1):4033] | PubMed: 37468473 |
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis [ Acta Pharmacol Sin, 2023, 10.1038/s41401-023-01156-w] | PubMed: 37696989 |
Tubular cell senescence promotes maladaptive kidney repair and chronic kidney disease after cisplatin nephrotoxicity [ JCI Insight, 2023, 8(8)e166643] | PubMed: 36917180 |
Post-translational modification of CDK1-STAT3 signaling by fisetin suppresses pancreatic cancer stem cell properties [ Cell Biosci, 2023, 13(1):176] | PubMed: 37743465 |
PPARγ activation by fisetin mitigates vascular smooth muscle cell senescence via the mTORC2-FoxO3a-autophagy signaling pathway [ Biochem Pharmacol, 2023, S0006-2952(23)00485-9] | PubMed: 37890594 |
Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment [ Geroscience, 2023, 45(5):2835-2850] | PubMed: 37296266 |
Fisetin, a Natural Polyphenol, Ameliorates Endometriosis Modulating Mast Cells Derived NLRP-3 Inflammasome Pathway and Oxidative Stress [ Int J Mol Sci, 2023, 24(6)5076] | PubMed: 36982152 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.