Emodin

Catalog No.S2295 Batch:S229505

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Technical Data

Formula

C15H10O5
Molecular Weight 270.24 CAS No. 518-82-1
Solubility (25°C)* In vitro DMSO 54 mg/mL (199.82 mM)
Ethanol 2 mg/mL (7.4 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
10%DMSO 40%PEG300 5%Tween80 45%ddH2O
3.7mg/ml Taking the 1 mL working solution as an example, add 100 μL of 37 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to make it clear; then continue to add 450 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Emodin is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, the buckthorn and Japanese Knotweed (Fallopia japonica).
Targets
11β-HSD1 [1]

Protocol (from reference)

Customer Product Validation

, , ACS Chem Biol, 2015, 10(4):978-88.

, , Mol Nutr Food Res, 2017, doi: 10.1002/mnfr.201600744

Data from [Data independently produced by , , Oncol Rep, 2017, 37(3):1565-1572]

Data from [Data independently produced by , , Xenobiotica, 2018, doi:10.1080/00498254.2018.1432087]

Selleck's Emodin has been cited by 16 publications

Emodin Inhibited Pathological Cardiac Hypertrophy in Response to Angiotensin-Induced Hypertension and Altered the Gut Microbiome [ Biomolecules, 2023, 13(9)1274] PubMed: 37759673
The In Vitro Anti-Parasitic Activities of Emodin toward Toxoplasma gondii [ Pharmaceuticals (Basel), 2023, 16(3)447] PubMed: 36986545
The In Vitro Anti-Parasitic Activities of Emodin toward Toxoplasma gondii [ Pharmaceuticals (Basel), 2023, 16(3)447] PubMed: 36986545
Systematic identification of biomarker-driven drug combinations to overcome resistance [ Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7] PubMed: 35332332
Emodin Ameliorates the Efficacy of Carfilzomib in Multiple Myeloma Cells via Apoptosis and Autophagy [ Biomedicines, 2022, 10(7)1638] PubMed: 35884943
Divergent and Overlapping Roles for Selected Phytochemicals in the Regulation of Pathological Cardiac Hypertrophy [ Molecules, 2021, 26(5)1210] PubMed: 33668293
Emodin and emodin-rich rhubarb inhibits histone deacetylase (HDAC) activity and cardiac myocyte hypertrophy. [ J Nutr Biochem, 2020, 79:108339] PubMed: 32007664
Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism [ Oncotarget, 2020, 11(46):4224-4242] PubMed: 33245718
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754
HSF1 phosphorylation by cyclosporin A confers hyperthermia sensitivity through suppression of HSP expression [ Biochim Biophys Acta Gene Regul Mech, 2019, 1862(8):846-857] PubMed: 31054961

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.