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Technical Data
| Formula | C23H25N5O5.CH4O3S |
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| Molecular Weight | 547.58 | CAS No. | 77883-43-3 | |
| Solubility (25°C)* | In vitro | DMSO | 27 mg/mL (49.3 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia. | |
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| In vitro | Doxazosin-induced apoptosis is blocked by specific caspase-8 inhibitors, supporting the functional involvement of caspase-8 in doxazosin-induced apoptosis. Doxazosin increases FADD recruitment and subsequent caspase-8 activation, implicating Fas-mediated apoptosis as the underlying mechanism of the effect of Doxazosin in prostate cells. [1] Doxazosin and cholestyramine similarly decreases plasma total and LDL plus VLDL cholesterols, and total triglycerides on average by 46%, 61% and 45% respectively. [2] Doxazosin induces DNA damage and cell death in HL-1 cell line. Doxazosin treatment decreases cell viability in primary cultures of neonatal rat cardiomyocytes, and Hoechst dye vital staining demonstrates doxazosin-induced apoptosis in primary cultures of human adult cardiomyocytes. [3] Doxazosin antagonizes the VEGF-mediated angiogenic response of HUVEC cells, by abrogating cell adhesion to fibronectin and collagen-coated surfaces and inhibiting cell migration, via a potential downregulation of VEGF expression. [4] | |
| In vivo | Doxazosin also reduces mean arterial pressure by 18% without affecting heart rate in all hamsters. [2] Doxazosin causes a significant reduction in the wet weight of BabeTGF-beta 1-infected mouse prostate reconstitution (MPR). [5] |
Protocol (from reference)
References
Customer Product Validation
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Data from [J Clin Invest, 2013, 123(12), 5119-34]
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Data from [Data independently produced by , , Prostate, 2016, 76(8):757-66]
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Data from [Data independently produced by , , J Ocul Pharmacol Ther, 2017, 33(1):50-56]
Selleck's Doxazosin Mesylate has been cited by 5 publications
| Suppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR [ J Exp Clin Cancer Res, 2023, 10.1186/s13046-023-02866-z] | PubMed: 37924112 |
| Antiangiogenic Effects of Doxazosin on Experimental Choroidal Neovascularization in Mice. [Guo J, et al. J Ocul Pharmacol Ther, 2017, 33(1):50-56] | PubMed: 27992238 |
| Relative cytotoxic potencies and cell death mechanisms of α1 -adrenoceptor antagonists in prostate cancer cell lines [Forbes A, et al. Prostate, 2016, 76(8):757-66] | PubMed: 26880388 |
| Irbesartan, an FDA approved drug for hypertension and diabetic nephropathy, is a potent inhibitor for hepatitis B virus entry by disturbing Na+-dependent taurocholate cotransporting polypeptide activity [Wang XJ, et al. Antiviral Res, 2015, 120:140-6] | PubMed: 26086883 |
| Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration. [Chen Y, et al. J Clin Invest, 2013, 123(12):5119-34] | PubMed: 24231350 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.