Dipyridamole

Catalog No.S1895 Batch:S189504

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Technical Data

Formula

C24H40N8O4
Molecular Weight 504.63 CAS No. 58-32-2
Solubility (25°C)* In vitro DMSO 100 mg/mL (198.16 mM)
Ethanol 50 mg/mL (99.08 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
10%DMSO 40%PEG300 5%Tween80 45%ddH2O
10.0mg/ml Taking the 1 mL working solution as an example, add 100 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify it; then continue to add 450 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Dipyridamole is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
Targets
PDE [1]

Protocol (from reference)

Selleck's Dipyridamole has been cited by 9 publications

Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805] PubMed: 39581704
Retinoblastoma vulnerability to combined de novo and salvage pyrimidine ribonucleotide synthesis pharmacologic blockage [ Heliyon, 2024, 10(1):e23831] PubMed: 38332874
Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity [ Haematologica, 2023, 108(9):2343-2357] PubMed: 37021547
Suppression of cell pyroptosis by omeprazole through PDE4-mediated autophagy in gastric epithelial cells. [ BIOCELL, 2023, 47(12): 2709-2719] PubMed: none
Histone methyltransferase GLP epigenetically activates GPCPD1 to sustain cancer cell metastasis and invasion [ Genome Instability & Disease , 2023, 4:21–37 ] PubMed: none
Wnt7b-induced Sox11 functions enhance self-renewal and osteogenic commitment of bone marrow mesenchymal stem cells [ Stem Cells, 2020, 38(8):1020-1033] PubMed: 32346881
Wnt7b-induced Sox11 functions enhance self-renewal and osteogenic commitment of bone marrow mesenchymal stem cells. [ Stem Cells, 2020, 28] PubMed: 32346881
Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes [Shen Q, et al. Am J Hum Genet, 2017, 100(1):5-20] PubMed: 27939638
PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma [ Oncogene, 2017, 36(23):3252-3262] PubMed: 28092671

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.