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Technical Data
| Formula | C45H72O16 |
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| Molecular Weight | 869.04 | CAS No. | 19057-60-4 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (115.06 mM) | |
| Ethanol | 25 mg/mL (28.76 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Dioscin (Collettiside III, Saponin) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp, showing antitumor activities. |
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| In vitro | Dioscin is extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively. [1] Dioscin induces apotosis in Hela cells by down regulating caspase-8 activity and up regulating caspase-9 activity. [2] |
| In vivo | LD50: Mice >300mg/kg [3] |
Protocol (from reference)
References
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Selleck's Dioscin has been cited by 7 publications
| Dioscin inhibits non-small cell lung cancer cells and activates apoptosis by downregulation of Survivin [ J Cancer, 2024, 15(5):1366-1377] | PubMed: 38356707 |
| Cannabidiol Does Not Impact Acute Anabolic or Inflammatory Signaling in Skeletal Muscle In Vitro [ Cannabis Cannabinoid Res, 2021, 10.1089/can.2021.0132] | PubMed: 34762497 |
| Dioscin induces ferroptosis and synergistic cytotoxicity with chemotherapeutics in melanoma cells [ Biochem Biophys Res Commun, 2021, 557:213-220] | PubMed: 33878610 |
| Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK. [ Mol Med Rep, 2020, 21(1):304-310] | PubMed: 31746382 |
| An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] | PubMed: 30900754 |
| Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression [Wang YC Int J Biol Sci, 2018, 14(1):47-56] | PubMed: 29483824 |
| Dioscin ameliorates cardiac hypertrophy through inhibition of the MAPK and Akt/GSK3β/mTOR pathways [Chen L Life Sci, 2018, 209:420-429] | PubMed: 30125581 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.