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Formula | C12H17NO2 |
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Molecular Weight | 207.27 | CAS No. | 29342-05-0 | ||||
Solubility (25°C)* | In vitro | DMSO | 41 mg/mL (197.8 mM) | ||||
Ethanol | 41 mg/mL (197.8 mM) | ||||||
Water | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Ciclopirox(HOE 296b, Penlac) is a broad-spectrum antifungal agent working as an iron chelator. | |
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Targets |
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In vitro | Ciclopirox olamine (CPX) is a lipophilic bidentate iron chelator that stabilizes HIF-1alpha under normoxic conditions at lower concentrations than other iron chelators, probably by inhibiting HIF-1alpha hydroxylation. Ciclopirox olamine (CPX)-induced HIF-1 mediates reporter gene activity and endogenous HIF-1 target gene expression, including elevation of transcription, mRNA, and protein levels of the vascular endothelial growth factor (VEGF).[1] Ciclopirox inhibits growth of C. albicans yeast and hyphal cells in a dose-dependent manner. [2] Ciclopirox blocks H2O2-induced mitochondrial injury by maintaining mitochondrial transmembrane potential (Deltapsim). Ciclopirox completely blocks H2O2-stimulated release of lactate dehydrogenase (a marker of cell death) and decreases in MTT reduction (a marker of mitochondrial function) in adenocarcinoma SK-HEP-1 cells. Ciclopirox effectively inhibits H2O2-induced mitochondrial permeability transition pore (MPTP) opening. [3] Ciclopirox increases the MTP, maintained it high, and blocks the ATP depletion in glucose-deprived SIN-1-treated astrocytes. Ciclopirox protects astrocytes from peroxynitritecytotoxicity by attenuating peroxynitrite-induced mitochondrial dysfunction. [4] Ciclopirox is a substituted pyridone antimycotic drug, unrelated to the imidazole derivatives and its topical application ensures maximum local bioavailability. Ciclopirox acts on fungi by inhibiting the intracellular uptake of essential substrates and ions and this probably acts on the Candida ability to express its adherence mechanisms. [5] |
Targeting of histone methyltransferase DOT1L plays a dual role in chemosensitization of retinoblastoma cells and enhances the efficacy of chemotherapy [ Cell Death Dis, 2021, 12(12):1141] | PubMed: 34887387 |
Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages [ J Transl Med, 2021, 19(1):347] | PubMed: 34389031 |
Protective Effect of Ciclopirox against Ovariectomy-Induced Bone Loss in Mice by Suppressing Osteoclast Formation and Function [ Int J Mol Sci, 2021, 22(15)8299] | PubMed: 34361069 |
MicroRNA-302a-3p induces ferroptosis of non-small cell lung cancer cells via targeting ferroportin [ Free Radic Res, 2021, 1-18] | PubMed: 34181495 |
High-throughput functional annotation of natural products by integrated activity profiling [ bioRxiv, 2019, 10.1101/748129] | PubMed: N/A |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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