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Technical Data
| Formula | C17H19ClN2S.HCl |
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| Molecular Weight | 355.33 | CAS No. | 69-09-0 | |
| Solubility (25°C)* | In vitro | DMSO | 71 mg/mL (199.81 mM) | |
| Water | 71 mg/mL (199.81 mM) | |||
| Ethanol | 71 mg/mL (199.81 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents. | ||
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| In vitro | Chlorpromazine affects miniature IPSCs (mIPSCs) by decreasing the binding (kon) and by increasing the unbinding (koff) rates of GABAARs. [1] Chlorpromazine modulates activated TRPA1 currents in a voltage-dependent way, leading to a block at positive potentials and an increased open probability at negative potentials. [2] | ||
| In vivo | Chlorpromazine independently down-regulates the production of various T cell-derived lymphokines (IL-2, IFN-gamma, IL-4, TNF, and GM-CSF) and up-regulates the secretion of IL-10 in an in vivo model of acute superantigen-driven immune activation. Chlorpromazine -mediated amplification of the SEB-driven Chlorpromazine secretion is accompanied by an enhanced IL-10 mRNA accumulation. [3] Chlorpromazine protects mice, normal or adrenalectomized, and guinea pigs against lethality of LPS, and inhibits TNF serum levels. Chlorpromazine protects against LPS lethality when administered 30 minutes (min) before, simultaneously, or up to 10 min after LPS and is ineffective when given 30 min after LPS, paralleling the inhibitory effect on TNF production. Chlorpromazine significantly inhibits LPS lethality and hepatotoxicity in mice sensitized to LPS toxicity by actinomycin D, whereas under these conditions DEX is inactive. [4] Chlorpromazine protects brain tissue from hypoxia-induced irreversible loss of synaptic transmission in rats. Chlorpromazine also significantly delays the occurrence of the hypoxia-induced spreading depression (SD) in rats. [5] |
Protocol (from reference)
References
Customer Product Validation
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, , Antimicrob Agents Chemother, 2014, 58:4875-4884.
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Data from [Data independently produced by , , Acta Biomater, 2018, 71:49-60]
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Data from [Data independently produced by , , Virology, 2018, 528:118-136]
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Data from [Data independently produced by , , Virol J, 2018, 15(1):92]
Selleck's Chlorpromazine HCl has been cited by 26 publications
| Peptide nanocarriers co-delivering an antisense oligonucleotide and photosensitizer elicit synergistic cytotoxicity [ J Colloid Interface Sci, 2024, 664:338-348] | PubMed: 38479270 |
| Tetrandrine (TET) inhibits African swine fever virus entry into cells by blocking the PI3K/Akt pathway [ Virus Res, 2024, 339:199258] | PubMed: 37923171 |
| Dextran sodium sulfate potentiates NLRP3 inflammasome activation by modulating the KCa3.1 potassium channel in a mouse model of colitis [ Cell Mol Immunol, 2022, 19(8):925-943] | PubMed: 35799057 |
| SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent manner [ Emerg Microbes Infect, 2022, 11(1):1135-1144] | PubMed: 35343395 |
| Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids [ PLoS Pathog, 2022, 18(6):e1010620] | PubMed: 35696443 |
| Channel catfish virus entry into host cells via clathrin-mediated endocytosis [ Virus Res, 2022, 315:198794] | PubMed: 35504448 |
| Porcine Deltacoronavirus (PDCoV) Entry into PK-15 Cells by Caveolae-Mediated Endocytosis [ Viruses, 2022, 14(3)496] | PubMed: 35336903 |
| Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells [ Theranostics, 2021, 11(5):2364-2380] | PubMed: 33500730 |
| Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells [ Theranostics, 2021, 11(5):2364-2380] | PubMed: 33500730 |
| Modification of Metal-Organic Framework Nanoparticles Using Dental Pulp Mesenchymal Stem Cell Membranes to Target Oral Squamous Cell Carcinoma [ J Colloid Interface Sci, 2021, 601:650-660] | PubMed: 34091312 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.