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Formula | C17H14F3N3O2S |
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Molecular Weight | 381.37 | CAS No. | 169590-42-5 | |
Solubility (25°C)* | In vitro | DMSO | 76 mg/mL (199.28 mM) | |
Ethanol | 76 mg/mL (199.28 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells. | ||
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In vitro | Celecoxib shows low sensitivity against COX-1 with IC50 of 15 μM. [1] Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 and CNE1-LMP1 with IC50 of 32.86 μM and 61.31 μM, respectively. [2] |
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In vivo | Celecoxib exhibits a potent, oral anti-inflammatory activity. Celecoxib reduces acute inflammation in the carrageenan edema assay and chronic inflammation in the adjuvant arthritis model with ED50 of 7.1 mg/kg and 0.37 mg/kg/day, respectively. In addition, Celecoxib also exhibits analgesic activity in the Hargreaves hyperalgesia model with ED50 of 34.5 mg/kg. Besides, Celecoxib produces no acute GI toxicity in rats at doses up to 200 mg/kg and no chronic GI toxicity in rats at doses up to 600 mg/kg/day over 10 days. [1] In a C3Hf/KamLaw female mouse model, Celecoxib increases median survival time of 105 days (range, 79-145 days) after 13.5 Gy local thoracic irradiation (LTI) alone to 142 days (range, 94-155 days). [3] |
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Data from [Br J Pharmacol, 2014, 171(2), 498-508]
Data from [Data independently produced by J Cell Physiol, 2014, 10.1002/jcp.24843]
Data from [Data independently produced by , , Science, 2018, 10(433), doi: 10.1126/scitranslmed.aar1916]
Data from [Data independently produced by , , J Transl Med, 2017, 15(1):46]
Leptin-mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer [ Cancer Commun (Lond), 2024, 10.1002/cac2.12583] | PubMed: 38958445 |
Therapeutic Anti-Tumor Efficacy of DC-Based Vaccines Targeting TME-Associated Antigens Is Improved When Combined with a Chemokine-Modulating Regimen and/or Anti-PD-L1 [ Vaccines (Basel), 2024, 12(7)777] | PubMed: 39066414 |
Modulation of autophagy and apoptosis can contribute to the anticancer effect of Abemaciclib/Celecoxib combination in colon cancer cells [ Med Oncol, 2024, 41(2):43] | PubMed: 38170401 |
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors [ Nat Cancer, 2023, 4(2):240-256] | PubMed: 36759733 |
MFSD2A potentiates gastric cancer response to anti-PD-1 immunotherapy by reprogramming the tumor microenvironment to activate T cell response [ Cancer Commun (Lond), 2023, 10.1002/cac2.12476] | PubMed: 37539769 |
Upregulation of β-catenin signaling represents a single common pathway leading to the various phenotypes of spinal degeneration and pain [ Bone Res, 2023, 11(1):18] | PubMed: 37059724 |
25-hydroxyvitamin D3 generates immunomodulatory plasticity in human periodontal ligament-derived mesenchymal stromal cells that is inflammatory context-dependent [ Front Immunol, 2023, 14:1100041] | PubMed: 36761739 |
COX-2/PGE2 upregulation contributes to the chromosome 17p-deleted lymphoma [ Oncogenesis, 2023, 12(1):5] | PubMed: 36750552 |
Phospholipid metabolic adaptation promotes survival of IDH2 mutant acute myeloid leukemia cells [ Cancer Sci, 2023, 10.1111/cas.15994] | PubMed: 37882467 |
Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells [ Toxicol Lett, 2023, 378:39-50] | PubMed: 36863539 |
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