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Formula | C17H15N7O2 |
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Molecular Weight | 349.35 | CAS No. | 1080622-86-1 | |
Solubility (25°C)* | In vitro | 4-Methylpyridine | 5 mg/mL warmed with 50ºC water bath (14.31 mM) | |
DMSO | 0.28 mg/mL (0.8 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | CP-466722 is a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells. | ||
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In vitro | In vitro, CP-466722 is identified as a potential inhibitor to decrease the activity of purified ATM kinase to phosphorylate GST-p53(1–101) substrate. In addition, CP-466722 also shows the inhibitory activities against abl and src kinases. [1] In HeLa cells, CP-466722 at doses of 6μM, results in the inhibition in ATM-dependent phosphorylation by reversibly inhibiting ionizing radiation (IR)-induced ATM kinase activity. Besides, ATM-dependent p53 induction is also inhibited by CP-466722 in MCF-7 human breast cancer cells and primary and immortalized diploid human fibroblasts. [1] In response to IR, CP-466722 increased proportion of cells with G2/M DNA content and reduces proportion of cells with G1-phase DNA content in HeLa cells. [1] Transient exposure to CP-466722 for a period of 4 hours sensitizes HeLa cells to IR without affecting cell plating nor cell viability. [1] |
Kinase Assay: |
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Cell Assay: |
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Data from [PLoS One, 2012, 7(11), e50423]
Data from [PLoS One, 2012, 7(11), e50423]
Data from [J Neurooncol, 2012, 110(3), 349-57]
Data from [J Neurooncol, 2012, 110(3), 349-57]
Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines [ G3 (Bethesda), 2020, 4;10(5):1585-1597] | PubMed: 32265286 |
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. [ Cell, 2019, 36(2):179-193] | PubMed: 28162770 |
A Pharmacogenomic Landscape in Human Liver Cancers. [ Cancer Cell, 2019, 36(2):179-193] | PubMed: 31378681 |
An Anticancer Drug Cocktail of Three Kinase Inhibitors Improved Response to a Dendritic Cell-Based Cancer Vaccine [ Cancer Immunol Res, 2019, 7(9):1523-1534] | PubMed: 31266784 |
Upregulation of long noncoding RNA SNHG20 promotes cell growth and metastasis in esophageal squamous cell carcinoma via modulating ATM-JAK-PD-L1 pathway [ J Cell Biochem, 2019, 10.1002/jcb.28444] | PubMed: 30767270 |
Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models. [ Mol Cells, 2019, 42(3):210-217] | PubMed: 30726661 |
ATM‑JAK‑PD‑L1 signaling pathway inhibition decreases EMT and metastasis of androgen‑independent prostate cancer. [ Mol Med Rep, 2018, 17(5):7045-7054] | PubMed: 29568923 |
Simultaneous targeting of ATM and Mcl-1 increases cisplatin sensitivity of cisplatin-resistant non-small cell lung cancer [ Cancer Biol Ther, 2017, 18(8):606-615] | PubMed: 28686074 |
Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model. [Mondesert O, et al. PLoS One, 2015, 10(7):e0134411] | PubMed: 26225756 |
ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells. [Nadkarni A, et al. J Neurooncol, 2012, 110(3):349-57] | PubMed: 23054561 |
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