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Technical Data
| Formula | C17H30N2O5 |
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| Molecular Weight | 342.43 | CAS No. | 88321-09-9 | |
| Solubility (25°C)* | In vitro | DMSO | 68 mg/mL (198.58 mM) | |
| Ethanol | 68 mg/mL (198.58 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellular entry of SARS-CoV-2 pseudovirions by 92.3%. | |
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| In vitro | Aloxistatin can enter the intact platelet and inhibit proteolysis by inhibiting calpain. [2] Aloxistatin blunts Parathyroid hormone (PTH)-induced cell proliferation and inhibits differentiation osteoblasts in vitro. [3] |
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| In vivo | Aloxistatin (100 mg/kg, p.o.) strongly inhibits the cathepsin B&L activities in the skeletal muscle, heart and liver of hamsters. [1] In spinal cord injury (SCI) rats, Aloxistatin provides neuroprotection in SCI lesion and penumbra. [4] Aloxistatin reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B activity. [5] |
Protocol (from reference)
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References
Selleck's Aloxistatin (E64d) has been cited by 43 publications
| Truncating NFKB1 variants cause combined NLRP3 inflammasome activation and type I interferon signaling and predispose to necrotizing fasciitis [ Cell Rep Med, 2024, 5(4):101503] | PubMed: 38593810 |
| Retinoic acid alleviates rotavirus-induced intestinal damage by regulating redox homeostasis and autophagic flux in piglets [ Anim Nutr, 2024, 20:16:409-421.] | PubMed: 38371474 |
| Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells [ Viruses, 2024, 16(11)1798] | PubMed: 39599912 |
| A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry [ Cell, 2023, 186(4):850-863.e16] | PubMed: 36803605 |
| Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53 [ Cell Rep, 2023, 42(12):113478] | PubMed: 37991919 |
| Cysteinyl leukotriene receptor 1 is a potent regulator of the endosomal-lysosomal system in the ARPE-19 retinal pigment epithelial cell line [ Traffic, 2023, 24(4):177-189] | PubMed: 36704929 |
| Canine distemper virus N protein induces autophagy to facilitate viral replication [ BMC Vet Res, 2023, 19(1):60] | PubMed: 36922800 |
| Canine distemper virus N protein induces autophagy to facilitate viral replication [ BMC Vet Res, 2023, 19(1):60] | PubMed: 36922800 |
| Babesia divergens egress from host cells is orchestrated by essential and druggable kinases and proteases [ Res Sq, 2023, rs.3.rs-2553721] | PubMed: 36909484 |
| Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike [ Cell, 2022, 185(12):2103-2115.e19] | PubMed: 35568035 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.