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Technical Data
| Formula | C21H22O9 |
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| Molecular Weight | 418.39 | CAS No. | 1415-73-2 | |
| Solubility (25°C)* | In vitro | DMSO | 84 mg/mL (200.76 mM) | |
| Water | 7 mg/mL (16.73 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Aloin (Barbaloin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor. | |
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| In vitro | Aloin, a natural anthracycline from Aloe vera, is a tyrosinase inhibitor with inhibitory rates of 2mM. [1] Aloin shows a pronounced antiproliferative effect at physiological concentration (IC50 = 97 μM), causes cell cycle arrest in the S phase and markedly increases HeLaS3 cell apoptosis (to 24%). [2] Aloin causes a reduction in the proportion of cells undergoing mitosis by induction of apoptosis, inhibition of topo II alpha protein expression and downregulation of cyclin B1 protein expression in MCF-7 cell line. [3] |
Protocol (from reference)
References
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Selleck's Aloin (Barbaloin) has been cited by 7 publications
| [Aloin inhibits gastric cancer cell proliferation and migration by suppressing the STAT3/HMGB1 signaling pathway] [ Nan Fang Yi Ke Da Xue Xue Bao, 2023, 43(5):702-709] | PubMed: 37313810 |
| Aloin decelerates the progression of hepatocellular carcinoma through circ_0011385/miR-149-5p/WT1 axis [ Cell Cycle, 2021, 10.1080/15384101.2021.1988227] | PubMed: 34720052 |
| Aloin Inhibits the Proliferation and Migration of Gastric Cancer Cells by Regulating NOX2-ROS-Mediated Pro-Survival Signal Pathways. [ Drug Des Devel Ther, 2020, 14:145-155] | PubMed: 32021099 |
| Quantitative determination of aloin, antioxidant activity, and toxicity of Aloe vera leaf gel products from Greece [ J Sci Food Agric, 2020, 10.1002/jsfa.10650] | PubMed: 32643805 |
| An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] | PubMed: 30900754 |
| The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1. [ Drug Des Devel Ther, 2019, 13:1221-1231] | PubMed: 31114162 |
| Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway. [ Cancer Med, 2019, 10.1002/cam4.2723] | PubMed: 31830378 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.