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Technical Data
| Formula | C27H28N2O3 |
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| Molecular Weight | 428.52 | CAS No. | 924416-43-3 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (233.36 mM) | |
| Ethanol | 50 mg/mL (116.68 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | AdipoRon (SC-396658) is a novel, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively. | ||||
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| In vitro | AdipoRon increases AMPK activation, PGC-1α expression and mitochondrial biogenesis by binding to both AdipoR1 and AdipoR2 in C2C12 myotubes. [1] | ||||
| In vivo | In skeletal muscle and liver of wild-type mice AdipoRon (50 mg/kg, i.v.) significantly induces phosphorylation of AMPK via AdipoR1 and AdipoR2. In WT mice, AdipoRon (50 mg/kg, p.o.) improves insulin resistance, glucose intolerance and dyslipidaemia by activating AdipoR1–AMPK–PGC-1α pathways in skeletal muscle, while by activating AdipoR2–PPAR-α pathways in the liver. Moreover, AdipoRon ameliorates diabetes of genetically obese rodent model db/db mice, and prolongs the shortened lifespan of db/db mice on a high-fat diet. [1] | ||||
| Features | Orally bioavailable adiponectin receptor agonist that can be used for the treatment of obesity-related diseases. |
Protocol (from reference)
Customer Product Validation
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Data from [Data independently produced by , , Mol Med Rep, 2018, 17(1):209-215]
Selleck's AdipoRon has been cited by 13 publications
| Organophosphorus Flame Retardants and Metabolic Disruption: An in Silico, in Vitro, and in Vivo Study Focusing on Adiponectin Receptors [ Environ Health Perspect, 2024, 132(11):117003] | PubMed: 39514743 |
| Small-molecule agonist AdipoRon alleviates diabetic retinopathy through the AdipoR1/AMPK/EGR4 pathway [ J Transl Med, 2024, 22(1):2] | PubMed: 38166990 |
| Overexpression of salusin‑β downregulates adipoR1 expression to prevent fatty acid oxidation in HepG2 cells [ Mol Med Rep, 2024, 29(2)18] | PubMed: 38063230 |
| Adiponectin suppresses tumor growth of nasopharyngeal carcinoma through activating AMPK signaling pathway [ J Transl Med, 2022, 20(1):89] | PubMed: 35164782 |
| Adiponectin Deficiency Promotes Endometrial Carcinoma Pathogenesis and Development via Activation of Mitogen-Activated Protein Kinase [ J Pathol, 2022, 10.1002/path.5874] | PubMed: 35072951 |
| SCA-1 micro-heterogeneity in the fate decision of dystrophic fibro/adipogenic progenitors [ Cell Death Dis, 2021, 12(1):122] | PubMed: 33495447 |
| Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy [ Cell Death Dis, 2021, 12(11):1031] | PubMed: 34718329 |
| SCA-1 micro-heterogeneity in the fate decision of dystrophic fibro/adipogenic progenitors [ Cell Death Dis, 2021, 12(1):122] | PubMed: 33495447 |
| An adiponectin receptor agonist promote osteogenesis via regulating bone-fat balance [ Cell Prolif, 2021, 54(6):e13035] | PubMed: 33939201 |
| AdipoRon Protects against Tubular Injury in Diabetic Nephropathy by Inhibiting Endoplasmic Reticulum Stress [ Oxid Med Cell Longev, 2020, 2020:6104375] | PubMed: 32832003 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.