Elraglusib

Catalog No.S9602 Batch:S960201

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Technical Data

Formula

C22H13FN2O5
Molecular Weight 404.35 CAS No. 1034895-42-5
Solubility (25°C)* In vitro DMSO 81 mg/mL (200.32 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO Corn oil
3.5mg/ml Taking the 1 mL working solution as an example, add 50 μL of 70 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Elraglusib(9-ING-41) is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.
Targets
GSK-3 [1]
In vitro

9-ING-41, a clinically relevant small molecule GSK-3β inhibitor with broad spectrum pre-clinical antitumor activity, suppresses the growth of neuroblastoma cells.[1] 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.[2]
In vivo

9-ING-41 has single-agent antitumor activity in a mouse model of MCL.[2] Mouse xenograft studies shows that the combination of clinically relevant doses of CPT-11 and 9-ING-41 lead to greater antitumor effect than is observed with either agent alone.[1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    Neuroblastoma cell lines SK-N-DZ, SK-N-BE

  • Concentrations

    0.1 μM–1 μM

  • Incubation Time

    48 h

  • Method

    Measurement of cell viability. Relative number of viable cancer cells is determined by measuring the optical density using CellTiter 96 Aqueous One Solution Cell Proliferation Assay kit according to the manufacturer’s instructions. A GI50 value for each compound is calculated with a non-linear regression model of standard slope using GraphPad Prism 6.0 software.
Animal Study:

[1]
  • Animal Models

    6–8 week-old female athymic nude mice

  • Dosages

    70 mg/kg

  • Administration

    IP

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.