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Technical Data
| Formula | C11H12N2O3 |
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| Molecular Weight | 220.22 | CAS No. | 56-69-9 | |
| Solubility (25°C)* | In vitro | DMSO | 44 mg/mL (199.8 mM) | |
| Water | 7 mg/mL (31.78 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | 5-Hydroxytryptophan (5-HTP, NSC-92523), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor for the treatment of depression. |
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| In vitro | 5-Hydroxytryptophan (5-HTP) is the intermediate metabolite of the essential amino acid L-tryptophan (LT) in the biosynthesis of serotonin. It easily crosses the blood-brain barrier and effectively increases central nervous system (CNS) synthesis of serotonin. Therapeutic administration of 5-HTP has been shown to be effective in treating a wide variety of conditions, including depression, fibromyalgia, binge eating associated with obesity, chronic headaches, and insomnia. [1] Clinical available evidence suggests 5-Hydroxytryptophan is better than placebo at alleviating depression. [2] |
| In vivo | LD50: Mice 1800mg/kg (i.g.); Rats 300mg/kg (i.g.) [3] |
Protocol (from reference)
References
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Selleck's 5-hydroxytryptophan (5-HTP) has been cited by 2 publications
| Role of 5-HT degradation in acute liver injury induced by carbon tetrachloride [ Eur J Pharmacol, 2021, 908:174355] | PubMed: 34280394 |
| Relationship between fatigue caused by type 2 diabetes mellitus and 5-HT degradation in skeletal muscle [ Acta Pharmaceutica Sinica, 2021, (1): 190-200] | PubMed: None |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.