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Technical Data
| Formula | C28 H18 N2 O6 |
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| Molecular Weight | 478.45 | CAS No. | 328998-25-0 | |
| Solubility (25°C)* | In vitro | DMSO | 96 mg/mL (200.64 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | 4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E. |
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Protocol (from reference)
Customer Product Validation
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Data from [Data independently produced by , , Front Immunol, 2017, 8:947]
Selleck's 4E1RCat has been cited by 8 publications
| A drug discovery pipeline for MAPK/ERK pathway inhibitors in C. elegans [ Cancer Res Commun, 2024, 10.1158/2767-9764.CRC-24-0221] | PubMed: 39212544 |
| Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2 [ Cell Chem Biol, 2021, S2451-9456(21)00213-0] | PubMed: 33979649 |
| Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression [ J Cell Mol Med, 2021, 10.1111/jcmm.16307] | PubMed: 33539648 |
| The expression of lacrimal androgen-binding proteins in mice Pseudomonas aeruginosa keratitis. [ Int J Ophthalmol, 2020, 13(1):7-10] | PubMed: 31956564 |
| The androgen receptor regulates a druggable translational regulon in advanced prostate cancer. [ Sci Transl Med, 2019, 11(503)] | PubMed: 31366581 |
| Proteomic analysis of Medulloblastoma reveals functional biology with translational potential. [ Acta Neuropathol Commun, 2018, 6(1):48] | PubMed: 29880060 |
| Osteopontin contributes to effective neutrophil recruitment, IL-1β production and apoptosis in Aspergillus fumigatus keratitis [ Immunol Cell Biol, 2018, 96(4):401-412] | PubMed: 29359350 |
| MicroRNA-21: A Positive Regulator for Optimal Production of Type I and Type III Interferon by Plasmacytoid Dendritic Cells [Liu F, et al. Front Immunol, 2017, 8:947] | PubMed: 28871250 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.