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Technical Data
| Formula | C10H7IN2 |
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| Molecular Weight | 282.08 | CAS No. | 41270-96-6 | |
| Solubility (25°C)* | In vitro | DMSO | 56 mg/mL (198.52 mM) | |
| Ethanol | 6 mg/mL (21.27 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | 4-IPP (4-Iodo-6-phenylpyrimidine) is an irreversible inhibitor of macrophage migration inhibitory factor (MIF) and a specific suicide substrate for MIF. 4-IPP can inhibit receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis and potentiate osteoblast-mediated mineralization and bone nodule formation in vitro. | |
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Protocol (from reference)
Selleck's 4-IPP has been cited by 3 publications
| Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells [ Mol Oncol, 2018, 12(8):1398-1409] | PubMed: 29896883 |
| Mutant KRAS-induced Macrophage Migration Inhibitory Factor (MIF) secretion promotes resistance to cetuximab in colorectal cancer [ SNU Open Repository, 2018, None] | PubMed: None |
| Mutant KRAS-induced Macrophage Migration Inhibitory Factor (MIF) secretion promotes resistance to cetuximab in colorectal cancer [ S-Space, 2018, N/A] | PubMed: N/A |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.