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Formula | C26H29NO2 |
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Molecular Weight | 387.51 | CAS No. | 68392-35-8 | ||||
Solubility (25°C)* | In vitro | DMSO | 78 mg/mL (201.28 mM) | ||||
Water | Insoluble | ||||||
Ethanol | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | 4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates on-target modification frequency for intein-Cas9 variants. |
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In vitro | 4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes[1]. 4-HT activates on-target modification frequency for intein-Cas9 variants [3]. |
Cell Assay: |
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Animal Study: |
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, , Oncogene, 2016, 36(16):2255-2264
The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation [ Nat Commun, 2024, 15(1):2983] | PubMed: 38582860 |
Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma [ Cell Rep Med, 2024, 5(3):101468] | PubMed: 38508144 |
LKB1 prevents ILC2 exhaustion to enhance antitumor immunity [ Cell Rep, 2024, S2211-1247(23)01591-7] | PubMed: 38670109 |
The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability [ Cell Rep, 2024, 43(2):113779] | PubMed: 38358891 |
Macrophages Promote Subtype Conversion and Endocrine Resistance in Breast Cancer [ Cancers (Basel), 2024, 16(3)678] | PubMed: 38339428 |
P53 Status Influences the Anti-proliferative Effect Induced by IFITM1 Inhibition in Estrogen Receptor-positive Breast Cancer Cells [ Cancer Genomics Proteomics, 2024, 21(5):511-522] | PubMed: 39191497 |
Novel Estrogen Receptor Dimerization BRET-Based Biosensors for Screening Estrogenic Endocrine-Disrupting Chemicals [ Biomater Res, 2024, 28:0010] | PubMed: 38464469 |
Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A [ Nat Commun, 2023, 14(1):5400] | PubMed: 37669939 |
Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A [ Nat Commun, 2023, 14(1):5400] | PubMed: 37669939 |
AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer [ Autophagy, 2023, 21:1-16.] | PubMed: 37733921 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.