4-Hydroxybenzyl alcohol

Catalog No.S3857 Batch:S385701

Technical Data

Formula	C₇H₈O₂
Molecular Weight	124.14	CAS No.	623-05-2
Solubility (25°C)*	In vitro	DMSO	24 mg/mL (193.33 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	4-hydroxybenzyl alcohol (P-Methylolphenol, 4-Methylolphenol), an important phenolic constituent of Gastrodia elata Blume (GEB), has been shown to have many beneficial effects in different animal models of neurological disorders, such as, headaches, convulsive behavior, dizziness, and vertigo.
In vitro	4-hydroxybenzyl alcohol has been shown to suppress inflammation, which is most probably due to its capability of reducing cyclooxygenase activity. HBA acts as a typical pleiotropic agent, which targets multiple mechanisms of angiogenesis, including production of angiogenic growth factors and MMPs, endothelial cell proliferation and migration as well as vascular sprouting and network formation^[1].
In vivo	4-hydroxybenzyl alcohol inhibits the vascularization of newly developing tumors and that this is associated with a reduced growth rate of the malignant tissue. It ameliorates cerebral ischaemic injury due to the inhibition of apoptotic pathways and the up-regulation of protein disulphide isomerase without inducing any toxic effects at doses up to 200 mg/kg. It exerts an anxiolytic-like action via the activation of the 5-hydroxytryptaminergic nervous system^[1].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines CT26.WT cell line Concentrations 1-100 mM Incubation Time 24 h Method Cells are cultured in presence of 1-100 mM HBA. Cells exposed to vehicle (DMSO) serve as control. After 24h, 10μL of WST-1 reagent per 100μL medium are added into each well. After 30min at 37°C, absorption is measured at 450 nm with 620 nm as reference using a microplate reader and corrected to blank values (wells without cells).
Animal Study:^{^[1]}	Animal Models BALB/c mice Dosages 200 mg/kg Administration i.p.

Cell Assay:^{^[1]}

Cell lines
CT26.WT cell line
Concentrations
1-100 mM
Incubation Time
24 h
Method
Cells are cultured in presence of 1-100 mM HBA. Cells exposed to vehicle (DMSO) serve as control. After 24h, 10μL of WST-1 reagent per 100μL medium are added into each well. After 30min at 37°C, absorption is measured at 450 nm with 620 nm as reference using a microplate reader and corrected to blank values (wells without cells).

Animal Study:^{^[1]}

Animal Models
BALB/c mice
Dosages
200 mg/kg
Administration
i.p.

References

[1] Laschke MW, et al. Life Sci. 2013, 93(1):44-50.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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