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Technical Data
| Formula | C7H8N2O |
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| Molecular Weight | 136.15 | CAS No. | 3544-24-9 | |
| Solubility (25°C)* | In vitro | DMSO | 27 mg/mL (198.31 mM) | |
| Ethanol | 27 mg/mL (198.31 mM) | |||
| Water | 22 mg/mL (161.58 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | 3-Aminobenzamide (3-ABA , 3-Amino Benzamide, 3-AB) is a potent inhibitor of Poly(ADP-ribose)polymerase (PARP) and inhibits cell apoptosis after SCI (Spinal Cord Injury) in caspase-independent way. | |
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Protocol (from reference)
References
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Customer Product Validation
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, , PLoS One, 2014, 9(10):e110776.
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Data from [Data independently produced by , , Brain Res, 2016, 1637:137-45. ]
Selleck's 3-Aminobenzamide has been cited by 6 publications
| ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury [ Int J Mol Sci, 2023, 24(2)1667] | PubMed: 36675183 |
| Sevoflurane exposure during the second trimester induces neurotoxicity in offspring rats by hyperactivation of PARP-1 [ Psychopharmacology (Berl), 2022, 10.1007/s00213-022-06188-4] | PubMed: 35859039 |
| Erlotinib protests against LPS-induced parthanatos through inhibiting macrophage surface TLR4 expression [ Cell Death Discov, 2021, 7(1):181] | PubMed: 34282120 |
| Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation. [ Acta Pharm Sin B, 2019, 9(4):782-793] | PubMed: 31384538 |
| Flavonoids of Rosa roxburghii Tratt Exhibit Anti-Apoptosis Properties by Regulating PARP-1/AIF [ J Cell Biochem, 2017, 118(11):3943-3952] | PubMed: 28398610 |
| Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells. [ J Biol Chem, 2015, 290(48):28675-82] | PubMed: 26429911 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.