3,4',5-Trimethoxy-trans-stilbene

Catalog No.S3888 Batch:S388801

Technical Data

Formula	C₁₇H₁₈O₃
Molecular Weight	270.32	CAS No.	22255-22-7
Solubility (25°C)*	In vitro	DMSO	54 mg/mL (199.76 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	3,4',5-Trimethoxy-trans-stilbene (MR-3) is a methylated derivative of resveratrol and shows more potent inhibitory effects on the growth of human cancer cells (HT-29, PC-3, COLO 205) with IC50 values of 81.31, 42.71 and 6.25 μM, respectively.
In vitro	Treatment with MR-3 at different concentrations ranging from 0 to 10 μM exhibits no cytotoxic effects on the A549 cells. MR-3 inhibits adhesion, migration, and invasion of A549 cells. The anti-invasive effects of MR-3 on A549 cells are likely mediated through the inhibition of phosphorylation of JNK and p38, as well as a reduction in the protein levels of nuclear factorkappa B (NF-kB) and activator protein-1 (AP-1) in the nucleus, ultimately leading to downregulation of MMP-2 expression^[1].

Description

3,4',5-Trimethoxy-trans-stilbene (MR-3) is a methylated derivative of resveratrol and shows more potent inhibitory effects on the growth of human cancer cells (HT-29, PC-3, COLO 205) with IC50 values of 81.31, 42.71 and 6.25 μM, respectively.

In vitro

Treatment with MR-3 at different concentrations ranging from 0 to 10 μM exhibits no cytotoxic effects on the A549 cells. MR-3 inhibits adhesion, migration, and invasion of A549 cells. The anti-invasive effects of MR-3 on A549 cells are likely mediated through the inhibition of phosphorylation of JNK and p38, as well as a reduction in the protein levels of nuclear factorkappa B (NF-kB) and activator protein-1 (AP-1) in the nucleus, ultimately leading to downregulation of MMP-2 expression^[1].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines A549 cells Concentrations 1, 5, 10, 25, 50, or 100 μM Incubation Time 24 h Method The A549 cells are treated with MR-3 at various concentrations (1, 5, 10, 25, 50, or 100 μM) for 24 h. Cell viability is assassed by MTT assay.

References

[1] Yang YT, et al. Mol Nutr Food Res. 2009, 53(3):407-16.

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SHIPPING AND STORAGE
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