1-Triacontanol

Catalog No.S5172 Batch:S517201

Technical Data

Formula	C₃₀H₆₂O
Molecular Weight	438.81	CAS No.	593-50-0
Solubility (25°C)*	In vitro	4-Methylpyridine	10 mg/mL warmed with 50ºC water bath (22.78 mM)
		Ethanol	1 mg/mL (2.27 mM)
		DMSO	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	1-Triacontanol (n-Triacontanol, Melissyl alcohol, Myricyl alcohol) is a fatty alcohol found in plant cuticle waxes and in beeswax. It is a growth stimulant for many plants, most notably roses.
In vivo	The area under concentration-time curve AUC_{0-6 h and AUC_0-∞ for 1-Triacontanol (TA) at 60 mg/kg are 87.737±13.574 and 93.617±17.62, respectively. The mean residence time is 3.25 ± 0.17 h. In addition, the elimination half-lives (t_1/2) are (2.37±1.23, 1.27±0.49, 2.07±0.93) h after single oral administration of 30, 60 and 120 mg/kg of TA. After oral administration, TA is extensively distributed in stomach and intestine. The majority of TA excrete via feces, and its accumulative excretion ratio during the period of 72 h is 26.68 ± 7.14%, but only 0.0023 ± 0.0015% and 0.0027 ± 0.0006% for urines and bile, respectively. The absolute bioavailability (F, %) of TA is about 2.0%. TA is regarded as a promising anti-cancer compound with less or no toxicity. Due to low bioavailability and undesirable half-life^[1].}

Description

1-Triacontanol (n-Triacontanol, Melissyl alcohol, Myricyl alcohol) is a fatty alcohol found in plant cuticle waxes and in beeswax. It is a growth stimulant for many plants, most notably roses.

In vivo

The area under concentration-time curve AUC_{0-6 h and AUC_0-∞ for 1-Triacontanol (TA) at 60 mg/kg are 87.737±13.574 and 93.617±17.62, respectively. The mean residence time is 3.25 ± 0.17 h. In addition, the elimination half-lives (t_1/2) are (2.37±1.23, 1.27±0.49, 2.07±0.93) h after single oral administration of 30, 60 and 120 mg/kg of TA. After oral administration, TA is extensively distributed in stomach and intestine. The majority of TA excrete via feces, and its accumulative excretion ratio during the period of 72 h is 26.68 ± 7.14%, but only 0.0023 ± 0.0015% and 0.0027 ± 0.0006% for urines and bile, respectively. The absolute bioavailability (F, %) of TA is about 2.0%. TA is regarded as a promising anti-cancer compound with less or no toxicity. Due to low bioavailability and undesirable half-life^[1].}

Protocol (from reference)

Animal Study:^{^[1]}	Animal Models Sprague-Dawley rats Dosages 60 mg/kg Administration oral administration

References

[1] Wang C, et al. Xenobiotica. 2015, 45(1):71-8.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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