1-Naphthyl PP1 hydrochloride

Catalog No.E2202 Batch:E220201

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Technical Data

Formula

C19H19N5.ClH
Molecular Weight 353.85 CAS No. 956025-47-1
Solubility (25°C)* In vitro DMSO 71 mg/mL (200.64 mM)
Ethanol 71 mg/mL (200.64 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of Src family kinases, inhibits v-Src, c-Fyn, c-Abl, CDK2 and CAMKII with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively.
Targets
c-Fyn [1]
(in vitro kinase assays)		 c-Abl [1]
(in vitro kinase assays)		 v-Src [1]
(in vitro kinase assays)		 CDK2 [1]
(in vitro kinase assays)		 CAMKII [1]
(in vitro kinase assays)
0.6 μM 0.6 μM 1.0 μM 18 μM 22 μM

Protocol (from reference)

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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